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Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study

There are limited data regarding health-related quality of life (HRQoL) in patients with ANCA-associated vasculitides (AAVs). We aimed to evaluate the HRQoL in patients with AAVs and compare it to another chronic inflammatory disease like RA and to healthy controls (HC). This was a multicentre, cros...

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Published in:Rheumatology (Oxford, England) England), 2024-02, Vol.63 (2), p.399
Main Authors: Panagiotopoulos, Alexandros, Thomas, Konstantinos, Argyriou, Evangelia, Chalkia, Aglaia, Kapsala, Noemin, Koutsianas, Christos, Mavrea, Evgenia, Petras, Dimitrios, Boumpas, Dimitrios T, Vassilopoulos, Dimitrios
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container_title Rheumatology (Oxford, England)
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creator Panagiotopoulos, Alexandros
Thomas, Konstantinos
Argyriou, Evangelia
Chalkia, Aglaia
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Koutsianas, Christos
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Petras, Dimitrios
Boumpas, Dimitrios T
Vassilopoulos, Dimitrios
description There are limited data regarding health-related quality of life (HRQoL) in patients with ANCA-associated vasculitides (AAVs). We aimed to evaluate the HRQoL in patients with AAVs and compare it to another chronic inflammatory disease like RA and to healthy controls (HC). This was a multicentre, cross-sectional study of patients with AAVs and RA recruited from three tertiary rheumatology clinics. HRQoL was assessed with the Short Form 36 Health Survey, which included the physical and mental component summary scores (PCS and MCS). Data from 1007 HC served as historical controls. Sixty-six patients with AAVs and 71 with RA were included. Both AAV and RA patients had significantly lower PCS and MCS scores compared with HC (P 
doi_str_mv 10.1093/rheumatology/kead214
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We aimed to evaluate the HRQoL in patients with AAVs and compare it to another chronic inflammatory disease like RA and to healthy controls (HC). This was a multicentre, cross-sectional study of patients with AAVs and RA recruited from three tertiary rheumatology clinics. HRQoL was assessed with the Short Form 36 Health Survey, which included the physical and mental component summary scores (PCS and MCS). Data from 1007 HC served as historical controls. Sixty-six patients with AAVs and 71 with RA were included. Both AAV and RA patients had significantly lower PCS and MCS scores compared with HC (P &lt; 0.05). HRQoL in AAV patients was worse in patients with microscopic polyangiitis compared with granulomatosis with polyangiitis (physical components) and those with high (VDI ≥ 3) vs low (VDI &lt; 3) damage scores while it did not differ between those with active (BVASv3 ≥ 1) vs. inactive (BVASv3 &lt; 1) disease. In contrast, in RA patients, HRQoL correlated both with disease activity (assessed by the DAS28-ESR) and functional impairment/damage (assessed by the HAQ). Although overall patients with RA had similar HRQoL compared with those with AAVs, those with active RA had worse HRQoL compared with those with active AAV. In patients with AAVs, HRQoL correlated more with organ damage and less with disease activity whereas in RA patients, it correlated with both. 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subjects Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Arthritis, Rheumatoid
Cross-Sectional Studies
Humans
Quality of Life
title Health-related quality of life in patients with ANCA vasculitides compared to rheumatoid arthritis: a cross-sectional comparative study
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