Effects of developmental exposures to Bisphenol-A and Bisphenol-S on hepatocellular function in male Long-Evans rats

• Published in: Life sciences (1973) 2023-08, Vol.326, p.121752-121752, Article 121752
• Main Authors: Liu, Keyi, Kadannagari, Surekha, Deruiter, Jack, Pathak, Suhrud, Abbott, Kodye L., Salamat, Julia M., Pondugula, Satyanarayana R., Akingbemi, Benson T., Dhanasekaran, Muralikrishnan
• Format: Article
• Language: English
• Subjects: Acute toxicity; Animals; Benzhydryl Compounds - toxicity; Bisphenol-A & Bisphenol-S; Carcinoma, Hepatocellular; Hepatotoxicity; Inflammation; Liver Neoplasms; Male; Oxidative stress; Postnatal; Rats; Rats, Long-Evans; Reactive Oxygen Species; Rodents (Long Evans)
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2023.121752

Bisphenol-S (BPS) is a current substitute for Bisphenol-A (BPA) in various commercial products (paper, plastics, protective can-coatings, etc.) used by all age groups globally. The current literature indicates that a drastic surge in pro-oxidants, pro-apoptotic, and pro-inflammatory biomarkers in combination with diminished mitochondrial activity can potentially decrease hepatic function leading to morbidity and mortality. Consequently, there are increasing public health concerns that substantial Bisphenol-mediated effects may impact hepatocellular functions, particularly in newborns exposed to BPA and BPS postnatally. However, the acute postnatal impact of BPA and BPS and the molecular mechanisms affecting hepatocellular functions are unknown. Therefore, the current study investigated the acute postnatal effect of BPA and BPS on the biomarkers of hepatocellular functions, including oxidative stress, inflammation, apoptosis, and mitochondrial activity in male Long-Evans rats. BPA and BPS (5 and 20 microgram/Liter (μg/L) of drinking water) were administered to 21-day-old male rats for 14 days. BPS had no significant effect on apoptosis, inflammation, and mitochondrial function but significantly reduced the reactive oxygen species (51–60 %, **p