Loading…

Visual Velocity Perception Dysfunction in Parkinson’s Disease

Compared with motor deficits, sensory information processing in Parkinson’s disease (PD) is relatively unexplored. While there is increasing interest in understanding the sensory manifestations of PD, the extent of sensory abnormality in PD has remained relatively unexplored. Furthermore, most inves...

Full description

Saved in:
Bibliographic Details
Published in:Behavioural brain research 2023-08, Vol.452, p.114490-114490, Article 114490
Main Authors: Bernardinis, Matthew, Atashzar, S. Farokh, Jog, Mandar S., Patel, Rajni V.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c305t-afe89eab14adc164f4028fcb13c39486773a1178454a78a2a8596912bde4dfbe3
container_end_page 114490
container_issue
container_start_page 114490
container_title Behavioural brain research
container_volume 452
creator Bernardinis, Matthew
Atashzar, S. Farokh
Jog, Mandar S.
Patel, Rajni V.
description Compared with motor deficits, sensory information processing in Parkinson’s disease (PD) is relatively unexplored. While there is increasing interest in understanding the sensory manifestations of PD, the extent of sensory abnormality in PD has remained relatively unexplored. Furthermore, most investigations on the sensory aspects of PD involve motor aspects, causing confounding results. As sensory deficits often arise in early PD development stages, they present a potential technological target for diagnosis and disease monitoring that is affordable and accessible. Considering this, the current study’s aim is to assess visual spatiotemporal perception independent of goal directed movements in PD by designing and using a scalable computational tool. A flexible 2-D virtual reality environment was created to evaluate various cases of visual perception. Using the tool, an experimental task quantifying the visual perception of velocity was tested on 37 individuals with PD and 17 age-matched control participants. Results: PD patients, both ON and OFF PD therapy, displayed perceptual impairments (p = 0.001 and p = 0.008, respectively) at slower tested velocity magnitudes. These impairments were even observed in early stages of PD (p = 0.015). Visual velocity perception is impaired in PD patients, which suggests impairments in visual spatiotemporal processing occur in PD and provides a promising modality to be used with disease monitoring software. Visual velocity perception shows high sensitivity to PD at all stages of the disease. Dysfunction in visual velocity perception may contribute to observed motor dysfunction in PD.
doi_str_mv 10.1016/j.bbr.2023.114490
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2813562577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166432823002085</els_id><sourcerecordid>2813562577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-afe89eab14adc164f4028fcb13c39486773a1178454a78a2a8596912bde4dfbe3</originalsourceid><addsrcrecordid>eNp9kL1OwzAQgC0EglJ4ABaUkSXFZzuxIwaEWv6kSnSArpbjXCSXNCl2gtSN1-D1eBJSWhiZ7obvPuk-Qs6AjoBCerkY5bkfMcr4CECIjO6RASjJYpmIbJ8MeiaNBWfqiByHsKCUCprAITniEiSTAgbkeu5CZ6pojlVjXbuOZugtrlrX1NFkHcqutj-7q6OZ8a-uDk399fEZookLaAKekIPSVAFPd3NIXu5un8cP8fTp_nF8M40tp0kbmxJVhiYHYQoLqSgFZaq0OXDLM6FSKbkBkEokwkhlmFFJlmbA8gJFUebIh-Ri61355q3D0OqlCxarytTYdEEzBTxJWdKLhgS2qPVNCB5LvfJuafxaA9Wbbnqh-256001vu_U35zt9ly-x-Lv4DdUDV1sA-yffHXodrMPaYuE82lYXjftH_w1D734a</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2813562577</pqid></control><display><type>article</type><title>Visual Velocity Perception Dysfunction in Parkinson’s Disease</title><source>Elsevier</source><creator>Bernardinis, Matthew ; Atashzar, S. Farokh ; Jog, Mandar S. ; Patel, Rajni V.</creator><creatorcontrib>Bernardinis, Matthew ; Atashzar, S. Farokh ; Jog, Mandar S. ; Patel, Rajni V.</creatorcontrib><description>Compared with motor deficits, sensory information processing in Parkinson’s disease (PD) is relatively unexplored. While there is increasing interest in understanding the sensory manifestations of PD, the extent of sensory abnormality in PD has remained relatively unexplored. Furthermore, most investigations on the sensory aspects of PD involve motor aspects, causing confounding results. As sensory deficits often arise in early PD development stages, they present a potential technological target for diagnosis and disease monitoring that is affordable and accessible. Considering this, the current study’s aim is to assess visual spatiotemporal perception independent of goal directed movements in PD by designing and using a scalable computational tool. A flexible 2-D virtual reality environment was created to evaluate various cases of visual perception. Using the tool, an experimental task quantifying the visual perception of velocity was tested on 37 individuals with PD and 17 age-matched control participants. Results: PD patients, both ON and OFF PD therapy, displayed perceptual impairments (p = 0.001 and p = 0.008, respectively) at slower tested velocity magnitudes. These impairments were even observed in early stages of PD (p = 0.015). Visual velocity perception is impaired in PD patients, which suggests impairments in visual spatiotemporal processing occur in PD and provides a promising modality to be used with disease monitoring software. Visual velocity perception shows high sensitivity to PD at all stages of the disease. Dysfunction in visual velocity perception may contribute to observed motor dysfunction in PD.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2023.114490</identifier><identifier>PMID: 37172741</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Computer-Generated Graphical Tool ; Non-Motor PD Symptoms ; Parkinson’s Disease (PD) ; PD Diagnostic Technology ; PD Monitoring Technology ; Visual Velocity Perception</subject><ispartof>Behavioural brain research, 2023-08, Vol.452, p.114490-114490, Article 114490</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-afe89eab14adc164f4028fcb13c39486773a1178454a78a2a8596912bde4dfbe3</cites><orcidid>0000-0002-6861-5218</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37172741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernardinis, Matthew</creatorcontrib><creatorcontrib>Atashzar, S. Farokh</creatorcontrib><creatorcontrib>Jog, Mandar S.</creatorcontrib><creatorcontrib>Patel, Rajni V.</creatorcontrib><title>Visual Velocity Perception Dysfunction in Parkinson’s Disease</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Compared with motor deficits, sensory information processing in Parkinson’s disease (PD) is relatively unexplored. While there is increasing interest in understanding the sensory manifestations of PD, the extent of sensory abnormality in PD has remained relatively unexplored. Furthermore, most investigations on the sensory aspects of PD involve motor aspects, causing confounding results. As sensory deficits often arise in early PD development stages, they present a potential technological target for diagnosis and disease monitoring that is affordable and accessible. Considering this, the current study’s aim is to assess visual spatiotemporal perception independent of goal directed movements in PD by designing and using a scalable computational tool. A flexible 2-D virtual reality environment was created to evaluate various cases of visual perception. Using the tool, an experimental task quantifying the visual perception of velocity was tested on 37 individuals with PD and 17 age-matched control participants. Results: PD patients, both ON and OFF PD therapy, displayed perceptual impairments (p = 0.001 and p = 0.008, respectively) at slower tested velocity magnitudes. These impairments were even observed in early stages of PD (p = 0.015). Visual velocity perception is impaired in PD patients, which suggests impairments in visual spatiotemporal processing occur in PD and provides a promising modality to be used with disease monitoring software. Visual velocity perception shows high sensitivity to PD at all stages of the disease. Dysfunction in visual velocity perception may contribute to observed motor dysfunction in PD.</description><subject>Computer-Generated Graphical Tool</subject><subject>Non-Motor PD Symptoms</subject><subject>Parkinson’s Disease (PD)</subject><subject>PD Diagnostic Technology</subject><subject>PD Monitoring Technology</subject><subject>Visual Velocity Perception</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAQgC0EglJ4ABaUkSXFZzuxIwaEWv6kSnSArpbjXCSXNCl2gtSN1-D1eBJSWhiZ7obvPuk-Qs6AjoBCerkY5bkfMcr4CECIjO6RASjJYpmIbJ8MeiaNBWfqiByHsKCUCprAITniEiSTAgbkeu5CZ6pojlVjXbuOZugtrlrX1NFkHcqutj-7q6OZ8a-uDk399fEZookLaAKekIPSVAFPd3NIXu5un8cP8fTp_nF8M40tp0kbmxJVhiYHYQoLqSgFZaq0OXDLM6FSKbkBkEokwkhlmFFJlmbA8gJFUebIh-Ri61355q3D0OqlCxarytTYdEEzBTxJWdKLhgS2qPVNCB5LvfJuafxaA9Wbbnqh-256001vu_U35zt9ly-x-Lv4DdUDV1sA-yffHXodrMPaYuE82lYXjftH_w1D734a</recordid><startdate>20230824</startdate><enddate>20230824</enddate><creator>Bernardinis, Matthew</creator><creator>Atashzar, S. Farokh</creator><creator>Jog, Mandar S.</creator><creator>Patel, Rajni V.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6861-5218</orcidid></search><sort><creationdate>20230824</creationdate><title>Visual Velocity Perception Dysfunction in Parkinson’s Disease</title><author>Bernardinis, Matthew ; Atashzar, S. Farokh ; Jog, Mandar S. ; Patel, Rajni V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-afe89eab14adc164f4028fcb13c39486773a1178454a78a2a8596912bde4dfbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Computer-Generated Graphical Tool</topic><topic>Non-Motor PD Symptoms</topic><topic>Parkinson’s Disease (PD)</topic><topic>PD Diagnostic Technology</topic><topic>PD Monitoring Technology</topic><topic>Visual Velocity Perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernardinis, Matthew</creatorcontrib><creatorcontrib>Atashzar, S. Farokh</creatorcontrib><creatorcontrib>Jog, Mandar S.</creatorcontrib><creatorcontrib>Patel, Rajni V.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernardinis, Matthew</au><au>Atashzar, S. Farokh</au><au>Jog, Mandar S.</au><au>Patel, Rajni V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual Velocity Perception Dysfunction in Parkinson’s Disease</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2023-08-24</date><risdate>2023</risdate><volume>452</volume><spage>114490</spage><epage>114490</epage><pages>114490-114490</pages><artnum>114490</artnum><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>Compared with motor deficits, sensory information processing in Parkinson’s disease (PD) is relatively unexplored. While there is increasing interest in understanding the sensory manifestations of PD, the extent of sensory abnormality in PD has remained relatively unexplored. Furthermore, most investigations on the sensory aspects of PD involve motor aspects, causing confounding results. As sensory deficits often arise in early PD development stages, they present a potential technological target for diagnosis and disease monitoring that is affordable and accessible. Considering this, the current study’s aim is to assess visual spatiotemporal perception independent of goal directed movements in PD by designing and using a scalable computational tool. A flexible 2-D virtual reality environment was created to evaluate various cases of visual perception. Using the tool, an experimental task quantifying the visual perception of velocity was tested on 37 individuals with PD and 17 age-matched control participants. Results: PD patients, both ON and OFF PD therapy, displayed perceptual impairments (p = 0.001 and p = 0.008, respectively) at slower tested velocity magnitudes. These impairments were even observed in early stages of PD (p = 0.015). Visual velocity perception is impaired in PD patients, which suggests impairments in visual spatiotemporal processing occur in PD and provides a promising modality to be used with disease monitoring software. Visual velocity perception shows high sensitivity to PD at all stages of the disease. Dysfunction in visual velocity perception may contribute to observed motor dysfunction in PD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37172741</pmid><doi>10.1016/j.bbr.2023.114490</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6861-5218</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0166-4328
ispartof Behavioural brain research, 2023-08, Vol.452, p.114490-114490, Article 114490
issn 0166-4328
1872-7549
language eng
recordid cdi_proquest_miscellaneous_2813562577
source Elsevier
subjects Computer-Generated Graphical Tool
Non-Motor PD Symptoms
Parkinson’s Disease (PD)
PD Diagnostic Technology
PD Monitoring Technology
Visual Velocity Perception
title Visual Velocity Perception Dysfunction in Parkinson’s Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T15%3A57%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Visual%20Velocity%20Perception%20Dysfunction%20in%20Parkinson%E2%80%99s%20Disease&rft.jtitle=Behavioural%20brain%20research&rft.au=Bernardinis,%20Matthew&rft.date=2023-08-24&rft.volume=452&rft.spage=114490&rft.epage=114490&rft.pages=114490-114490&rft.artnum=114490&rft.issn=0166-4328&rft.eissn=1872-7549&rft_id=info:doi/10.1016/j.bbr.2023.114490&rft_dat=%3Cproquest_cross%3E2813562577%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c305t-afe89eab14adc164f4028fcb13c39486773a1178454a78a2a8596912bde4dfbe3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2813562577&rft_id=info:pmid/37172741&rfr_iscdi=true