Biodegradable Poly(trehalose) Nanoparticle for Preventing Amyloid Beta Aggregation and Related Neurotoxicity

Trehalose is a disaccharide that is capable of inhibiting protein aggregation and activating cellular autophagy. It has been shown that a polymer or nanoparticle form, terminated with multiple trehalose units, can significantly enhance the anti-amyloidogenic performance and is suitable for the treat...

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Bibliographic Details
Published in:ACS applied bio materials 2023-06, Vol.6 (6), p.2102-2110
Main Authors: Mandal, Suman, Jana, Debabrata, Dolai, Jayanta, Sarkar, Ankan Kumar, Ghorai, Binay K., Jana, Nikhil R.
Format: Article
Language:English
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Summary:Trehalose is a disaccharide that is capable of inhibiting protein aggregation and activating cellular autophagy. It has been shown that a polymer or nanoparticle form, terminated with multiple trehalose units, can significantly enhance the anti-amyloidogenic performance and is suitable for the treatment of neurodegenerative diseases. Here, we report a trehalose-conjugated polycarbonate-co-lactide polymer and formulation of its nanoparticles having multiple numbers of trehalose exposed on the surface. The resultant poly­(trehalose) nanoparticle inhibits the aggregation of amyloid beta peptides and disintegrates matured amyloid fibrils into smaller fragments. Moreover, the poly­(trehalose) nanoparticle lowers extracellular amyloid β oligomer-driven cellular stress and enhances cell viability. The presence of biodegradable polycarbonate components in the poly­(trehalose) nanoparticle would enhance their application potential as an anti-amyloidogenic material.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.2c00771