Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Long non-coding RNAs (lncRNAs) are a class of noncoding RNAs with a length larger than 200 nucleotides that participate in various diseases and biological processes as they can control gene expression by different mechanisms. Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder character...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2023-06, Vol.246, p.154512-154512, Article 154512
Main Authors: Elazazy, Ola, Midan, Heba M., Shahin, Reem K., Elesawy, Ahmed E., Elballal, Mohammed S., Sallam, Al-Aliaa M., Elbadry, Abdullah M.M., Elrebehy, Mahmoud A., Bhnsawy, Abdelmenem, Doghish, Ahmed S.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Biomarkers - metabolism
Clinical implications
Humans
Long non-coding RNAs (lncRNAs)
Pathogenesis
Rheumatoid arthritis (RA)
RNA, Long Noncoding - genetics
RNA, Untranslated
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long non-coding RNAs (lncRNAs) are a class of noncoding RNAs with a length larger than 200 nucleotides that participate in various diseases and biological processes as they can control gene expression by different mechanisms. Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder characterized by symmetrical destructive destruction of distal joints as well as extra-articular involvement. Different studies have documented and proven the abnormal expression of lncRNAs in RA patients. Various lncRNAs have proven potential as biomarkers and targets for diagnosing, prognosis and treating RA. This review will focus on RA pathogenesis, clinical implications, and related lncRNA expressions that help to identify new biomarkers and treatment targets.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154512