Extracellular volume fraction of the pancreas predicts glucose intolerance in patients undergoing major pancreatic surgeries

•Native pancreatic T1 value and ECV were both positively correlated with preoperative HbA1c value.•ECV > 30.7% was an independent predictor for newly-onset diabetes mellitus after surgery.•ECV > 30.7% was an independent predictor for worsened glucose tolerance after surgery. Pancreatic T1 valu...

Full description

Saved in:
Bibliographic Details
Published in:European journal of radiology 2023-07, Vol.164, p.110859-110859, Article 110859
Main Authors: Zhu, Liang, Wang, Shitian, Sun, Zhaoyong, Liu, Jingyi, Dai, Menghua, Han, Xianlin, Xu, Qiang, Li, Naishi, Dominik Nickel, Marcel, Xue, Huadan, Jin, Zhengyu
Format: Article
Language:English
Subjects:
Diabetes mellitus
Extracellular volume fraction
Pancreas
T1 mapping
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Native pancreatic T1 value and ECV were both positively correlated with preoperative HbA1c value.•ECV > 30.7% was an independent predictor for newly-onset diabetes mellitus after surgery.•ECV > 30.7% was an independent predictor for worsened glucose tolerance after surgery. Pancreatic T1 value and extracellular volume fraction (ECV) are potential imaging biomarkers for pancreatic exocrine and endocrine function. This study aims to evaluate the ability of native T1 value and ECV of the pancreas in predicting postoperative new-onset diabetes (NODM) and worsened glucose tolerance in patients undergoing major pancreatic surgeries. This retrospective study involved 73 patients who underwent 3 T pancreatic MRI with pre- and postcontrast T1 mapping before major pancreatic surgeries. Patients were divided into non-diabetic, pre-diabetic and diabetic groups based on their glycated hemoglobin (HbA1c) value. Preoperative native T1 value and ECV of the pancreas were compared among the three groups. The correlation of pancreatic T1 value and ECV with HbA1c was assessed by linear regression analysis, and the ability of pancreatic T1 value and ECV for predicting postoperative NODM and worsened glucose tolerance was assessed using Cox Proportional hazards regression analysis. Native pancreatic T1 value and ECV were both significantly higher in diabetic patients compared to pre-diabetic/non-diabetic patients, and ECV was also significantly higher in pre-diabetic patients compared to non-diabetic patients (all p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2023.110859