Hippocampal rotation is associated with ventricular atrial size

Background Fetal ventriculomegaly is a source of apprehension for expectant parents and may present prognostic uncertainty for physicians. Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association betw...

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Bibliographic Details
Published in:Pediatric radiology 2023-08, Vol.53 (9), p.1941-1950
Main Authors: Whitehead, Matthew T., Limperopoulos, Catherine, Schlatterer, Sarah D., Mulkey, Sarah B., Fraser, Jamie L., du Plessis, Adre J.
Format: Article
Language:English
Subjects:
Atria
Atrial Fibrillation - complications
Differential diagnosis
Female
Fetuses
Gestational age
Health care facilities
Hemorrhage
Hippocampus
Humans
Hydrocephalus - diagnostic imaging
Imaging
Infant
Medicine
Medicine & Public Health
Morphology
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Patients
Pediatrics
Pregnancy
Prenatal Diagnosis
Radiology
Retrospective Studies
Rotation
Ultrasonography, Prenatal
Ultrasound
Ventricle
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Summary:Background Fetal ventriculomegaly is a source of apprehension for expectant parents and may present prognostic uncertainty for physicians. Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association between ventriculomegaly and incomplete hippocampal inversion. Objective To determine whether ventricular size is related to incomplete hippocampal inversion. Materials and methods We retrospectively evaluated pre- and postnatal brain MRIs in normal subjects (mean GA, 31 weeks; mean postnatal age, 27 days) and patients with isolated ventriculomegaly (mean GA, 31 weeks; mean postnatal age, 68 days) at a single academic medical center. Lateral ventricular diameter, multiple qualitative and quantitative markers of hippocampal inversion, and evidence of intraventricular hemorrhage were documented. Results Incomplete hippocampal inversion and ventricular size were associated in both normal subjects ( n =51) and patients with ventriculomegaly ( n =32) ( P
ISSN:1432-1998
0301-0449
1432-1998
DOI:10.1007/s00247-023-05687-6