Hippocampal rotation is associated with ventricular atrial size

Background Fetal ventriculomegaly is a source of apprehension for expectant parents and may present prognostic uncertainty for physicians. Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association betw...

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Published in:Pediatric radiology 2023-08, Vol.53 (9), p.1941-1950
Main Authors: Whitehead, Matthew T., Limperopoulos, Catherine, Schlatterer, Sarah D., Mulkey, Sarah B., Fraser, Jamie L., du Plessis, Adre J.
Format: Article
Language:English
Subjects:
Atria
Atrial Fibrillation - complications
Differential diagnosis
Female
Fetuses
Gestational age
Health care facilities
Hemorrhage
Hippocampus
Humans
Hydrocephalus - diagnostic imaging
Imaging
Infant
Medicine
Medicine & Public Health
Morphology
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Patients
Pediatrics
Pregnancy
Prenatal Diagnosis
Radiology
Retrospective Studies
Rotation
Ultrasonography, Prenatal
Ultrasound
Ventricle
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container_end_page 1950
container_issue 9
container_start_page 1941
container_title Pediatric radiology
container_volume 53
creator Whitehead, Matthew T.
Limperopoulos, Catherine
Schlatterer, Sarah D.
Mulkey, Sarah B.
Fraser, Jamie L.
du Plessis, Adre J.
description Background Fetal ventriculomegaly is a source of apprehension for expectant parents and may present prognostic uncertainty for physicians. Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association between ventriculomegaly and incomplete hippocampal inversion. Objective To determine whether ventricular size is related to incomplete hippocampal inversion. Materials and methods We retrospectively evaluated pre- and postnatal brain MRIs in normal subjects (mean GA, 31 weeks; mean postnatal age, 27 days) and patients with isolated ventriculomegaly (mean GA, 31 weeks; mean postnatal age, 68 days) at a single academic medical center. Lateral ventricular diameter, multiple qualitative and quantitative markers of hippocampal inversion, and evidence of intraventricular hemorrhage were documented. Results Incomplete hippocampal inversion and ventricular size were associated in both normal subjects ( n =51) and patients with ventriculomegaly ( n =32) ( P
doi_str_mv 10.1007/s00247-023-05687-6
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Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association between ventriculomegaly and incomplete hippocampal inversion. Objective To determine whether ventricular size is related to incomplete hippocampal inversion. Materials and methods We retrospectively evaluated pre- and postnatal brain MRIs in normal subjects (mean GA, 31 weeks; mean postnatal age, 27 days) and patients with isolated ventriculomegaly (mean GA, 31 weeks; mean postnatal age, 68 days) at a single academic medical center. Lateral ventricular diameter, multiple qualitative and quantitative markers of hippocampal inversion, and evidence of intraventricular hemorrhage were documented. Results Incomplete hippocampal inversion and ventricular size were associated in both normal subjects ( n =51) and patients with ventriculomegaly ( n =32) ( P &lt;0.05). Severe ventriculomegaly was significantly associated with adverse clinical outcome in postnatal ( P =0.02) but not prenatal ( P =0.43) groups. In all additional cases of isolated ventriculomegaly, clinical outcome was normal over the time of assessment (mean 1±1.9 years; range 0.01 to 10 years). Conclusion Lateral ventricular atrial diameter and incomplete hippocampal inversion are associated. Less hippocampal inversion correlates with larger atria. For every 1-mm increase in fetal ventricular size, the odds of incomplete hippocampal inversion occurring increases by a factor of 1.6 in normal controls and 1.4 in patients with ventriculomegaly. Graphical Abstract</description><identifier>ISSN: 1432-1998</identifier><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-023-05687-6</identifier><identifier>PMID: 37183230</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atria ; Atrial Fibrillation - complications ; Differential diagnosis ; Female ; Fetuses ; Gestational age ; Health care facilities ; Hemorrhage ; Hippocampus ; Humans ; Hydrocephalus - diagnostic imaging ; Imaging ; Infant ; Medicine ; Medicine &amp; Public Health ; Morphology ; Neuroradiology ; Nuclear Medicine ; Oncology ; Original Article ; Patients ; Pediatrics ; Pregnancy ; Prenatal Diagnosis ; Radiology ; Retrospective Studies ; Rotation ; Ultrasonography, Prenatal ; Ultrasound ; Ventricle</subject><ispartof>Pediatric radiology, 2023-08, Vol.53 (9), p.1941-1950</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-1b0d878155d588c5f745bc75e309ba98961ac1aded66f9eed1a9f3a49567fbeb3</cites><orcidid>0000-0001-5077-693X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37183230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitehead, Matthew T.</creatorcontrib><creatorcontrib>Limperopoulos, Catherine</creatorcontrib><creatorcontrib>Schlatterer, Sarah D.</creatorcontrib><creatorcontrib>Mulkey, Sarah B.</creatorcontrib><creatorcontrib>Fraser, Jamie L.</creatorcontrib><creatorcontrib>du Plessis, Adre J.</creatorcontrib><title>Hippocampal rotation is associated with ventricular atrial size</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Background Fetal ventriculomegaly is a source of apprehension for expectant parents and may present prognostic uncertainty for physicians. Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association between ventriculomegaly and incomplete hippocampal inversion. Objective To determine whether ventricular size is related to incomplete hippocampal inversion. Materials and methods We retrospectively evaluated pre- and postnatal brain MRIs in normal subjects (mean GA, 31 weeks; mean postnatal age, 27 days) and patients with isolated ventriculomegaly (mean GA, 31 weeks; mean postnatal age, 68 days) at a single academic medical center. Lateral ventricular diameter, multiple qualitative and quantitative markers of hippocampal inversion, and evidence of intraventricular hemorrhage were documented. Results Incomplete hippocampal inversion and ventricular size were associated in both normal subjects ( n =51) and patients with ventriculomegaly ( n =32) ( P &lt;0.05). Severe ventriculomegaly was significantly associated with adverse clinical outcome in postnatal ( P =0.02) but not prenatal ( P =0.43) groups. In all additional cases of isolated ventriculomegaly, clinical outcome was normal over the time of assessment (mean 1±1.9 years; range 0.01 to 10 years). Conclusion Lateral ventricular atrial diameter and incomplete hippocampal inversion are associated. Less hippocampal inversion correlates with larger atria. For every 1-mm increase in fetal ventricular size, the odds of incomplete hippocampal inversion occurring increases by a factor of 1.6 in normal controls and 1.4 in patients with ventriculomegaly. 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Accurate prenatal counseling requires knowledge of its cause and associated findings as the differential diagnosis is broad. We have observed an association between ventriculomegaly and incomplete hippocampal inversion. Objective To determine whether ventricular size is related to incomplete hippocampal inversion. Materials and methods We retrospectively evaluated pre- and postnatal brain MRIs in normal subjects (mean GA, 31 weeks; mean postnatal age, 27 days) and patients with isolated ventriculomegaly (mean GA, 31 weeks; mean postnatal age, 68 days) at a single academic medical center. Lateral ventricular diameter, multiple qualitative and quantitative markers of hippocampal inversion, and evidence of intraventricular hemorrhage were documented. Results Incomplete hippocampal inversion and ventricular size were associated in both normal subjects ( n =51) and patients with ventriculomegaly ( n =32) ( P &lt;0.05). Severe ventriculomegaly was significantly associated with adverse clinical outcome in postnatal ( P =0.02) but not prenatal ( P =0.43) groups. In all additional cases of isolated ventriculomegaly, clinical outcome was normal over the time of assessment (mean 1±1.9 years; range 0.01 to 10 years). Conclusion Lateral ventricular atrial diameter and incomplete hippocampal inversion are associated. Less hippocampal inversion correlates with larger atria. For every 1-mm increase in fetal ventricular size, the odds of incomplete hippocampal inversion occurring increases by a factor of 1.6 in normal controls and 1.4 in patients with ventriculomegaly. Graphical Abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37183230</pmid><doi>10.1007/s00247-023-05687-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5077-693X</orcidid></addata></record>
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identifier ISSN: 1432-1998
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subjects Atria
Atrial Fibrillation - complications
Differential diagnosis
Female
Fetuses
Gestational age
Health care facilities
Hemorrhage
Hippocampus
Humans
Hydrocephalus - diagnostic imaging
Imaging
Infant
Medicine
Medicine & Public Health
Morphology
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Patients
Pediatrics
Pregnancy
Prenatal Diagnosis
Radiology
Retrospective Studies
Rotation
Ultrasonography, Prenatal
Ultrasound
Ventricle
title Hippocampal rotation is associated with ventricular atrial size
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