Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia

Summary We explored the association of novel urinary biomarkers with albumin‐creatinine ratio (ACR) in adults with sickle cell anaemia. Of 37 participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin (p = 0.002), retinol‐binding protein 4 (p = 0.008), alpha‐1 microglobuli...

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Bibliographic Details
Published in:British journal of haematology 2023-08, Vol.202 (3), p.669-673
Main Authors: Elsherif, Laila, Kanthakumar, Praghalathan, Afolabi, Jeremiah, Stratton, Ashley F., Ogu, Ugochi, Nelson, Marquita, Mukhopadhyay, Ayesha, Smeltzer, Matthew P., Adebiyi, Adebowale, Ataga, Kenneth I.
Format: Article
Language:English
Subjects:
Adult
Albuminuria - urine
alpha‐1 microglobulin
Anemia
Anemia, Sickle Cell
Angiotensinogen
Angiotensinogen - urine
Biomarkers - urine
Clusterin
Creatinine
Creatinine - urine
Hematology
Humans
Kidney diseases
Kidney Diseases - urine
persistent albuminuria
retinol‐binding protein 4
Sickle cell anemia
Sickle cell disease
Vitamin A
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Summary:Summary We explored the association of novel urinary biomarkers with albumin‐creatinine ratio (ACR) in adults with sickle cell anaemia. Of 37 participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin (p = 0.002), retinol‐binding protein 4 (p = 0.008), alpha‐1 microglobulin (p = 0.002) and angiotensinogen (p = 0.006) were significantly higher in participants with PA than in those without PA. Although univariate analysis showed significant associations between both alpha‐1 microglobulin (p = 0.035) and angiotensinogen (p = 0.0021) with ACR, only angiotensinogen was associated with ACR in multivariable analysis (p = 0.04). Our results suggest that urinary angiotensinogen may identify sickle cell anaemia patients at risk for kidney disease.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18862