The intestinal mucosal barrier - A key player in rheumatoid arthritis?

Rheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical ba...

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Bibliographic Details
Published in:Clinical anatomy (New York, N.Y.) N.Y.), 2023-10, Vol.36 (7), p.977-985
Main Authors: Li, Jing, Jia, Nini, Cui, Mengyao, Li, Yaqing, Li, Xiang, Chu, Xiaoqin
Format: Article
Language:English
Subjects:
Arthritis
Autoimmune diseases
Barriers
Dynamic stability
Intestine
Microflora
Mucosa
Pathogenesis
Rheumatoid arthritis
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Summary:Rheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical barrier, immune barrier, and microflora barrier. It is a dynamic system that contributes to the stability of the intestinal environment by regulating the absorption of relevant substances from the lumen into the circulation, while limiting the passage of harmful substances. This article summarizes the connection between the intestinal mucosa barrier and RA, and proposes the role of relevant Chinese medicines on RA from the point of improving barriers, to provide new perspectives on the pathogenesis and therapeutic strategies of RA.
ISSN:0897-3806
1098-2353
DOI:10.1002/ca.24055