Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs

ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particula...

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Published in:Epigenomics 2023-03, Vol.15 (5), p.307-334
Main Authors: Farokhian, Alireza, Rajabi, Ali, Sheida, Amirhossein, Abdoli, Amirhossein, Rafiei, Moein, Jazi, Zahra Hadian, Asouri, Sahar Ahmadi, Morshedi, Mohammad Amin, Hamblin, Michael R, Adib-Hajbagheri, Parisa, Mirzaei, Hamed
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - genetics
circRNA
exosome
Humans
lncRNA
MicroRNAs - genetics
miRNAs
myocardial infarction
Myocardial Infarction - genetics
ncRNAs
RNA, Circular
RNA, Untranslated - genetics
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Summary:ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2022-0451