Caution may be required in using l-theanine in diabetes mellitus: A study on the rats

The study aimed to identify the effects of l-theanine on kidney and heart tissues in diabetic rats. 24 male rats included in the study were divided into 4 groups (n = 6/group): SHAM, LTEA, DM and DM + LTEA. For 28 days, drinking water was given to SHAM and DM, and LTEA (200 mg/kg/day) to LTEA and DM...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2023-07, Vol.666, p.170-178
Main Authors: Vanizor Kural, Birgül, Azi Mohamed, Sabrina, Kör, Sevil, Arıkan Malkoç, Meltem, Yuluğ, Esin, Hajizadeh Tekmeh, Hamed, Örem, Asım
Format: Article
Language:English
Subjects:
ACE2
Animals
Cystatin C
Diabetes
Diabetes Mellitus, Experimental - metabolism
Glutamates - pharmacology
Glutathione Disulfide - metabolism
Homocysteine
Iron
Kidney - pathology
L-theanine
Male
Rats
Rats, Sprague-Dawley
Streptozocin
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Summary:The study aimed to identify the effects of l-theanine on kidney and heart tissues in diabetic rats. 24 male rats included in the study were divided into 4 groups (n = 6/group): SHAM, LTEA, DM and DM + LTEA. For 28 days, drinking water was given to SHAM and DM, and LTEA (200 mg/kg/day) to LTEA and DM + LTEA groups, intragastrically. DM was induced by 120 mg/kg nicotinamide (NA) + 60 mg/kg streptozotocin (STZ). The levels of cystatin C (CysC) and angiotensin-converting enzyme 2 (ACE2) were determined by ELISA kits, homocysteine, electrolytes and iron by an autoanalyzer, the ratio of oxidized/total reduced glutathione (GSSG/TGSH) by assay kits. The tissues were histopathologically analyzed. LTEA alleviated histopathological degenerations. However, it decreased significantly serum iron and homocysteine levels (p 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2023.04.095