In vitro laboratory models of proliferative vitreoretinopathy

Proliferative vitreoretinopathy (PVR), the most common cause of recurrent retinal detachment, is characterized by the formation and contraction of fibrotic membranes on the surface of the retina. There are no Food and Drug Administration (FDA)-approved drugs to prevent or treat PVR. Therefore, it is...

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Bibliographic Details
Published in:Survey of ophthalmology 2023-09, Vol.68 (5), p.861-874
Main Authors: Gao, Ashley Y., Haak, Andrew J., Bakri, Sophie J.
Format: Article
Language:English
Subjects:
Animal
Cell culture
Chip
Eye
Humans
Hydrogel
Membrane
Organoid
Proliferative vitreoretinopathy
Retina
Retinal cell culture
Retinal Detachment
Vitreoretinopathy, Proliferative - drug therapy
Vitreoretinopathy, Proliferative - metabolism
Vitreous
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Summary:Proliferative vitreoretinopathy (PVR), the most common cause of recurrent retinal detachment, is characterized by the formation and contraction of fibrotic membranes on the surface of the retina. There are no Food and Drug Administration (FDA)-approved drugs to prevent or treat PVR. Therefore, it is necessary to develop accurate in vitro models of the disease that will enable researchers to screen drug candidates and prioritize the most promising candidates for clinical studies. We provide a summary of recent in vitro PVR models, as well as avenues for model improvement. Several in vitro PVR models were identified, including various types of cell cultures. Additionally, novel techniques that have not been used to model PVR were identified, including organoids, hydrogels, and organ-on-a-chip models. Novel ideas for improving in vitro PVR models are highlighted. Researchers may consult this review to help design in vitro models of PVR, which will aid in the development of therapies to treat the disease.
ISSN:0039-6257
1879-3304
DOI:10.1016/j.survophthal.2023.05.007