Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors

Chiral materials have drawn the widespread attention for their its chiral recognition ability. The design and synthesis of chiral material are of importance owing to the unpredictability in controlling chirality during the synthesis process. To circumvent problems, a chiral MOF (D-His-ZIF-8) was syn...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2023-06, Vol.190 (6), p.230-230, Article 230
Main Authors: Niu, Xiaohui, Zhao, Rui, Yan, Simeng, Li, Hongxia, Yang, Jing, Cao, Kunjie, Liu, Xiaoyu, Wang, Kunjie
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Analytical Chemistry
Biosensing Techniques
Biosensors
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chiral materials
Chirality
Cobalt
Detectors
Electric properties
Enantiomers
Histidine
Medical equipment
Metal-organic frameworks
Microengineering
Nanochannels
Nanochemistry
Nanotechnology
Original Paper
Physiological apparatus
Polymer industry
Polymers
Polymers - chemistry
Recognition
Stereoisomerism
Synthesis
Transition metals
Tryptophan
Tryptophan - chemistry
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Summary:Chiral materials have drawn the widespread attention for their its chiral recognition ability. The design and synthesis of chiral material are of importance owing to the unpredictability in controlling chirality during the synthesis process. To circumvent problems, a chiral MOF (D-His-ZIF-8) was synthesized by ligand exchange of 2-methylimidazole (Hmim) on ZIF-8 by D-histidine (D-His), which can be treated as chiral host to distinguish amino acid enantiomers. The obtained D-His-ZIF-8 can provide chiral nanochannels for amino acid guests. Meanwhile, polynary transition-metal ion (Co 2+ and Fe 3+ ) coordinating with polydopamine (PDA) wrapped on the surface of D-His-ZIF-8 can increase the active sites. The electrochemical chiral recognition behavior showed that D-His-ZIF-8@CoFe-PDA exhibited good recognition of the tryptophan enantiomer (L/D-Trp) (working potential of −0.2 V vs. Hg/HgCl 2 ). The LOD and LOQ of L-Trp were 0.066 mM and 0.22 mM, respectively, while the LOD and LOQ of D-Trp were 0.15 mM and 0.50 mM, respectively. Finally, the usefulness of D-His-ZIF-8@CoFe-PDA/GCE was evaluated with a recovery of 94.4–103%. The analysis of real  samples shows that D-His-ZIF-8@CoFe-PDA/GCE is a feasible sensing platform for the detection of L-Trp and D-Trp. Graphical abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-023-05807-x