Factors associated with spontaneous miscarriage risk in IUI treatment: A retrospectively cohort of 31,933 cycles

•IUI miscarriage rate is related to female age, spontaneous miscarriage history and ovarian stimulation schemes.•Gonadotrophin is more effective in intrauterine insemination reducing miscarriage rate for patients without spontaneous miscarriage history when ovarian induction is needed.•Combining use...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2023-07, Vol.286, p.61-68
Main Authors: Luo, Qiongxiu, Qin, Jiaying, Wang, Huan, Hu, Yinyan, Yang, Lan, Mao, Taifeng, Yi, Ling, Liu, Wenyan, Zeng, Qiao, Qiu, Yu
Format: Article
Language:English
Subjects:
Abortion rate
Abortion, Spontaneous - epidemiology
Adult
Clomiphene
Clomiphene - therapeutic use
Female
Gonadotropin
Gonadotropins - therapeutic use
Humans
Insemination, Artificial - methods
IUI
Ovarian induction
Ovulation Induction - adverse effects
Ovulation Induction - methods
Pregnancy
Pregnancy Rate
Retrospective Studies
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Summary:•IUI miscarriage rate is related to female age, spontaneous miscarriage history and ovarian stimulation schemes.•Gonadotrophin is more effective in intrauterine insemination reducing miscarriage rate for patients without spontaneous miscarriage history when ovarian induction is needed.•Combining use of clomiphene and gonadotrophin showed the lowest miscarriage rate for women with spontaneous miscarriage history when ovarian induction was needed. To determine the factors associated with intrauterine insemination (IUI) miscarriages and reduce the IUI miscarriage rate, a retrospective study was performed by reviewing 31,933 IUI cycles from 2006 to 2018. The overall there were 14.50% clinical pregnancies, and 16.74% miscarriages. Logistic regression revealed the following three predictive variables: females aged ≥ 35 years (odds ratio [OR] = 2.131; p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2023.05.005