Small Cell Carcinoma of the Rectum—An Unexpected Diagnosis: Current Treatment Options for a Rare and Aggressive Entity

Rectal small cell carcinoma is a rare and aggressive cancer subtype for which a consensus of optimal treatment has not yet been reached. This cancer presents a difficult surgical problem, and thus, the mainstay of treatment tends to mirror that of small cell carcinoma of the lung (chemotherapy, radi...

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Bibliographic Details
Published in:The American surgeon 2023-12, Vol.89 (12), p.6359-6361
Main Authors: Evangelisti, Taylor M., Platoff, Rebecca M., Khrizman, Polina, Morrison, Jamin C., Joneja, Upasana, Allen, Ashleigh A., Giugliano, Danica N., Kwiatt, Michael E., McClane, Steven J.
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - therapy
Humans
Prospective Studies
Rectal Neoplasms - diagnosis
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Rectum - pathology
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Summary:Rectal small cell carcinoma is a rare and aggressive cancer subtype for which a consensus of optimal treatment has not yet been reached. This cancer presents a difficult surgical problem, and thus, the mainstay of treatment tends to mirror that of small cell carcinoma of the lung (chemotherapy, radiation therapy, and immune modulators). This brief report highlights current treatment options available for this rare and difficult entity. There is a significant need for large-center clinical trials and prospective studies to help determine the best treatment regimen to effectively care for patients with small cell carcinoma of the rectum.
ISSN:0003-1348
1555-9823
DOI:10.1177/00031348231175116