Spectral computed tomography-guided radiotherapy of osteosarcoma utilizing BiOI nanosheets

• Published in: Acta biomaterialia 2023-08, Vol.166, p.615-626
• Main Authors: Fu, Zi, Li, Kun, Wang, Han, Li, Yuhan, Zhang, Jian, Zhou, Jingwei, Hu, Jiajia, Xie, Dong, Ni, Dalong
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Contrast agents; Contrast Media; Dual-energy computed tomography; Humans; Osteosarcoma; Osteosarcoma - diagnostic imaging; Osteosarcoma - radiotherapy; Radiosensitizers; Signal-To-Noise Ratio; Tomography; Tomography, X-Ray Computed - methods
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2023.05.026

As an aggressive malignant bone tumor, osteosarcoma (OS) is usually found in children and adolescents. Computed tomography (CT) is an important tool for the clinical evaluation of osteosarcoma, but limits to low diagnostic specificity due to single parameters of traditional CT and modest signal-to-noise ratio of clinical iodinated contrast agents. As one kind of spectral CT, dual-energy CT (DECT), with the advantage of a provision of multi-parameter information, makes it possible to acquire the best signal-to-noise ratio image, accurate detection, as well as imaging-guided therapy of bone tumors. Hereby, we synthesized BiOI nanosheets (BiOI NSs) as a DECT contrast agent with superior imaging capability compared to iodine agents for clinical detection of OS. Meanwhile, the synthesized BiOI NSs with great biocompatibility is able to achieve effective radiotherapy (RT) by enhancing X-ray dose deposition at the tumor site, leading to DNA damage, which in turn inhibits tumor growth. This study offers a promising new avenue for DECT imaging-guided treatment of OS. Osteosarcoma (OS) is a common primary malignant bone tumor. Traditional surgical procedures and conventional CT scans are often used for the treatment and monitoring of OS, but the effects are generally unsatisfactory. In this work, BiOI nanosheets (NSs) was reported for dual-energy CT (DECT) imaging-guided OS radiotherapy. The powerful and constant X-ray absorption of BiOI NSs at any energy guarantees excellent enhanced DECT imaging performance, allowing detailed visualization of OS through images with a better signal-to-noise ratio and guiding radiotherapy process. The deposition of X-rays could be greatly enhanced by Bi atoms to induce serious DNA damage in radiotherapy. Taken together, the BiOI NSs for DECT-guided radiotherapy will greatly improve the current treatment status of OS. [Display omitted]