Silver-catalyzed synthesis of nitrogen heterocycles: recent advancements

• Published in: Organic & biomolecular chemistry 2023-05, Vol.21 (21), p.4332-4357
• Main Authors: Devi, P. S, Neetha, Mohan, Anilkumar, Gopinathan
• Format: Article
• Language: English
• Subjects: Agricultural industry; Atom economy; Catalysis; Chemical synthesis; Chemistry; Economic development; Fabrication; Nitrogen; Recyclability; Regioselectivity; Silver
• ISSN: 1477-0520; 1477-0539
• DOI: 10.1039/d3ob00277b

Heterocyclic chemistry is an ever-expanding field without boundaries. Heterocycles play a significant role in medicinal and pharmaceutical chemistry, the agricultural industry and materials science. Among heterocycles, N-heterocycles constitute a large family. Their ubiquity in living and non-living systems makes them an endless topic for research. Being a part of the research community, we need to balance environmental concerns with scientific and economic development. So, research that is coherent with nature is a trending domain at all times. Silver catalysis possesses a greener face in organic synthesis. The simple, rich and extensive chemistry shown by silver makes it an attractive choice for catalysis. Inspired by its versatility and uniqueness we have compiled here recent developments in the silver-catalyzed synthesis of nitrogen-containing heterocycles since 2019. The high efficiency, regioselectivity, chemoselectivity, recyclability of the catalytic system, greater atom economy and simple reaction setup are the major highlights of this protocol. It is a hot research topic which is evident from the large number of works carried out for the fabrication of a range of N-heterocycles with varying complexities. Silver catalysis offers environmentally friendly and simple protocols to construct N-heterocycles. Inspired by its appeal, herein we have summarized developments in the silver-catalyzed synthesis of N-heterocycles since 2019.