First description of Candida haemulonii infecting a snake Boa constrictor: Molecular, pathological and antifungal sensitivity characteristics

Candida haemulonii is an emergent infectious pathogen that affects human presenting comorbidities and/or immunodepression. Little is known about other possible hosts. For the first time, this fungus was found causing a cutaneous infection in a snake, Boa constrictor, characterized by scale opacity a...

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Bibliographic Details
Published in:Microbial pathogenesis 2023-07, Vol.180, p.106164-106164, Article 106164
Main Authors: Fonseca, Maísa Santos, Deegan, Kathleen Ramos, Tomé, Luiz Marcelo, Mendonça, Marcos Antonio, Sokolonski, Ana Rita, Gondim, Leane Queiroz, Azevedo, Vasco, Meyer, Roberto, Tasic, Ljubica, Góes-Neto, Aristóteles, Portela, Ricardo Wagner
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Antifungals
Boidae
Candida
Candidiasis
Candidiasis - microbiology
Emergent diseases
Fluconazole - pharmacology
Fluconazole - therapeutic use
Humans
Metal Nanoparticles
Microbial Sensitivity Tests
Phylogeny
Silver - pharmacology
Wildlife
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Summary:Candida haemulonii is an emergent infectious pathogen that affects human presenting comorbidities and/or immunodepression. Little is known about other possible hosts. For the first time, this fungus was found causing a cutaneous infection in a snake, Boa constrictor, characterized by scale opacity and several ulcerative lesions. This C. haemulonii was isolated, identified using molecular techniques and a phylogenetic study, and had its growth totally inhibited by all the drugs tested; however, no fungicide effect was seen for fluconazole and itraconazole. The B. constrictor clinical signals subsided after a treatment using a biogenic silver nanoparticle-based ointment. These findings, along with the B. constrictor presence near human habitats, warn for the necessity of wildlife health monitoring for emergent and opportunistic diseases in peri-urban environments.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2023.106164