miRNAs as potential game-changers in retinoblastoma: Future clinical and medicinal uses

Retinoblastoma (RB) is a rare tumor in children, but it is the most common primitive intraocular malignancy in childhood age, especially those below three years old. The RB gene (RB1) undergoes mutations in individuals with RB. Although mortality rates remain high in developing countries, the surviv...

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Published in:Pathology, research and practice research and practice, 2023-07, Vol.247, p.154537-154537, Article 154537
Main Authors: Doghish, Ahmed S., Moustafa, Hebatallah Ahmed Mohamed, Elballal, Mohammed S., Sarhan, Omnia M., Darwish, Samar F., Elkalla, Wagiha S., Mohammed, Osama A., Atta, Asmaa M., Abdelmaksoud, Nourhan M., El-Mahdy, Hesham A., Ismail, Ahmed, Abdel Mageed, Sherif S., Elrebehy, Mahmoud A., Abdelfatah, Amr M., Abulsoud, Ahmed I.
Format: Article
Language:English
Subjects:
Child
Child, Preschool
Diagnosis
Drug resistance
Humans
MicroRNAs - genetics
MiRNA
Mutation
Prognosis
Retinal Neoplasms - genetics
Retinal Neoplasms - therapy
Retinoblastoma (RB)
Retinoblastoma - genetics
Retinoblastoma - therapy
Therapeutic intervention
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Summary:Retinoblastoma (RB) is a rare tumor in children, but it is the most common primitive intraocular malignancy in childhood age, especially those below three years old. The RB gene (RB1) undergoes mutations in individuals with RB. Although mortality rates remain high in developing countries, the survival rate for this type of cancer is greater than 95–98% in industrialized countries. However, it is lethal if left untreated, so early diagnosis is essential. As a non-coding RNA, miRNA significantly impacts RB development and treatment resistance because it can control various cellular functions. In this review, we illustrate the recent advances in the role of miRNAs in RB. That includes the clinical importance of miRNAs in RB diagnosis, prognosis, and treatment. Moreover, the regulatory mechanisms of miRNAs in RB and therapeutic interventions are discussed.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154537