The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature

Multiple myeloma (MM) is a plasma cells neoplasm which is often preceded by a preneoplastic condition called monoclonal gammopathy of unknown significance (MGUS). A protein called High-mobility group box-1 (HMGB-1) controls transcription and genomic stability. Both pro- and anti-tumor properties of...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2023-07, Vol.247, p.154562-154562, Article 154562
Main Authors: Casciaro, Marco, Vincelli, Donatella, Ferraro, Maria, Mirabile, Giuseppe, Pace, Elisabetta, Martino, Bruno, Tonacci, Alessandro, Gangemi, Sebastiano, Pioggia, Giovanni, Allegra, Alessandro
Format: Article
Language:English
Subjects:
Alarmins
High-mobility group box-1
HMGB1 Protein
Humans
Inflammation
Monoclonal gammopathies of uncertain significance
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Paraproteinemias
Psoriasin
RAGE
S100 Calcium Binding Protein A7
Tumorigenesis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c348t-ad13200e5bf15cc52cb502770fe592c9fbefb1f32bc50b23fef19109f52d8f943
container_end_page 154562
container_issue
container_start_page 154562
container_title Pathology, research and practice
container_volume 247
creator Casciaro, Marco
Vincelli, Donatella
Ferraro, Maria
Mirabile, Giuseppe
Pace, Elisabetta
Martino, Bruno
Tonacci, Alessandro
Gangemi, Sebastiano
Pioggia, Giovanni
Allegra, Alessandro
description Multiple myeloma (MM) is a plasma cells neoplasm which is often preceded by a preneoplastic condition called monoclonal gammopathy of unknown significance (MGUS). A protein called High-mobility group box-1 (HMGB-1) controls transcription and genomic stability. Both pro- and anti-tumor properties of HMGB1 have been described during tumor growth. The S100 protein family includes a protein known as psoriasin. Poorer prognosis and survival were linked to higher psoriasin expression in cancer patients. The goal of the current investigation was to compare the plasma levels of HMGB-1 and psoriasin in patients with MM and MGUS significance, as well as in a group of healthy controls. According to our research, patients with MGUS have higher HMGHB-1 concentrations than healthy controls (846.7 ± 287.6 pg/ml vs. 176.9 ± 204.8 pg/ml for controls, p 
doi_str_mv 10.1016/j.prp.2023.154562
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2818055391</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033823002625</els_id><sourcerecordid>2818055391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-ad13200e5bf15cc52cb502770fe592c9fbefb1f32bc50b23fef19109f52d8f943</originalsourceid><addsrcrecordid>eNp9kc2OFCEURonROO3oA7gxLN1Uy09RXaWrycSZMZlEF-OaAHXppgMFQpVar-OTStujSxMSEnK-k8v9EHpNyZYS2r07blNOW0YY31LRio49QRva0b4hHadP0Ybwtm0I5_0FelHKkRCyIy19ji74jtFu13Yb9OvhADhHDzhafOf2hyZE7bybV7zPcUlYx58NxWoa8ZcSs1PFTbiesPjZpRoLK_gY1Ht8NSm_FldOIoVTTItXs4sTVtaCmWHEesUhTtH4WFG8VyHEpOaDg_LHn-G7gx-n-FxnqiNAVvOS4SV6ZpUv8OrxvkRfbz4-XN81959vP11f3TeGt_3cqJFyRggIbakwRjCjBWG7HbEgBmYGq8FqajnTRhDNuAVLB0oGK9jY26Hll-jt2Zty_LZAmWVwxYD3aoK4FMl62hMh-EArSs-oybGUDFam7ILKq6REnqqRx_qS5Kkaea6mZt486hcdYPyX-NtFBT6cAaifrKvIshgHk4HR5bpAOUb3H_1v2NSiHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2818055391</pqid></control><display><type>article</type><title>The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature</title><source>ScienceDirect Freedom Collection</source><creator>Casciaro, Marco ; Vincelli, Donatella ; Ferraro, Maria ; Mirabile, Giuseppe ; Pace, Elisabetta ; Martino, Bruno ; Tonacci, Alessandro ; Gangemi, Sebastiano ; Pioggia, Giovanni ; Allegra, Alessandro</creator><creatorcontrib>Casciaro, Marco ; Vincelli, Donatella ; Ferraro, Maria ; Mirabile, Giuseppe ; Pace, Elisabetta ; Martino, Bruno ; Tonacci, Alessandro ; Gangemi, Sebastiano ; Pioggia, Giovanni ; Allegra, Alessandro</creatorcontrib><description>Multiple myeloma (MM) is a plasma cells neoplasm which is often preceded by a preneoplastic condition called monoclonal gammopathy of unknown significance (MGUS). A protein called High-mobility group box-1 (HMGB-1) controls transcription and genomic stability. Both pro- and anti-tumor properties of HMGB1 have been described during tumor growth. The S100 protein family includes a protein known as psoriasin. Poorer prognosis and survival were linked to higher psoriasin expression in cancer patients. The goal of the current investigation was to compare the plasma levels of HMGB-1 and psoriasin in patients with MM and MGUS significance, as well as in a group of healthy controls. According to our research, patients with MGUS have higher HMGHB-1 concentrations than healthy controls (846.7 ± 287.6 pg/ml vs. 176.9 ± 204.8 pg/ml for controls, p &lt; 0.001). Similarly, we found a huge difference in HMGB-1 levels for MM patients with respect to controls (928.0 ± 551.4 pg/ml vs. 176.9 ± 204.8 pg/ml; p = 0.001). No difference was found as for the Psoriasin levels in the three groups considered. Additionally, we tried to evaluate the knowledge already present in the literature about putative mechanisms of action for these molecules in the onset and development of these disorders.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2023.154562</identifier><identifier>PMID: 37216746</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Alarmins ; High-mobility group box-1 ; HMGB1 Protein ; Humans ; Inflammation ; Monoclonal gammopathies of uncertain significance ; Monoclonal Gammopathy of Undetermined Significance ; Multiple Myeloma ; Paraproteinemias ; Psoriasin ; RAGE ; S100 Calcium Binding Protein A7 ; Tumorigenesis</subject><ispartof>Pathology, research and practice, 2023-07, Vol.247, p.154562-154562, Article 154562</ispartof><rights>2023 Elsevier GmbH</rights><rights>Copyright © 2023 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-ad13200e5bf15cc52cb502770fe592c9fbefb1f32bc50b23fef19109f52d8f943</cites><orcidid>0000-0001-6156-8239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37216746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casciaro, Marco</creatorcontrib><creatorcontrib>Vincelli, Donatella</creatorcontrib><creatorcontrib>Ferraro, Maria</creatorcontrib><creatorcontrib>Mirabile, Giuseppe</creatorcontrib><creatorcontrib>Pace, Elisabetta</creatorcontrib><creatorcontrib>Martino, Bruno</creatorcontrib><creatorcontrib>Tonacci, Alessandro</creatorcontrib><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><creatorcontrib>Pioggia, Giovanni</creatorcontrib><creatorcontrib>Allegra, Alessandro</creatorcontrib><title>The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Multiple myeloma (MM) is a plasma cells neoplasm which is often preceded by a preneoplastic condition called monoclonal gammopathy of unknown significance (MGUS). A protein called High-mobility group box-1 (HMGB-1) controls transcription and genomic stability. Both pro- and anti-tumor properties of HMGB1 have been described during tumor growth. The S100 protein family includes a protein known as psoriasin. Poorer prognosis and survival were linked to higher psoriasin expression in cancer patients. The goal of the current investigation was to compare the plasma levels of HMGB-1 and psoriasin in patients with MM and MGUS significance, as well as in a group of healthy controls. According to our research, patients with MGUS have higher HMGHB-1 concentrations than healthy controls (846.7 ± 287.6 pg/ml vs. 176.9 ± 204.8 pg/ml for controls, p &lt; 0.001). Similarly, we found a huge difference in HMGB-1 levels for MM patients with respect to controls (928.0 ± 551.4 pg/ml vs. 176.9 ± 204.8 pg/ml; p = 0.001). No difference was found as for the Psoriasin levels in the three groups considered. Additionally, we tried to evaluate the knowledge already present in the literature about putative mechanisms of action for these molecules in the onset and development of these disorders.</description><subject>Alarmins</subject><subject>High-mobility group box-1</subject><subject>HMGB1 Protein</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Monoclonal gammopathies of uncertain significance</subject><subject>Monoclonal Gammopathy of Undetermined Significance</subject><subject>Multiple Myeloma</subject><subject>Paraproteinemias</subject><subject>Psoriasin</subject><subject>RAGE</subject><subject>S100 Calcium Binding Protein A7</subject><subject>Tumorigenesis</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEURonROO3oA7gxLN1Uy09RXaWrycSZMZlEF-OaAHXppgMFQpVar-OTStujSxMSEnK-k8v9EHpNyZYS2r07blNOW0YY31LRio49QRva0b4hHadP0Ybwtm0I5_0FelHKkRCyIy19ji74jtFu13Yb9OvhADhHDzhafOf2hyZE7bybV7zPcUlYx58NxWoa8ZcSs1PFTbiesPjZpRoLK_gY1Ht8NSm_FldOIoVTTItXs4sTVtaCmWHEesUhTtH4WFG8VyHEpOaDg_LHn-G7gx-n-FxnqiNAVvOS4SV6ZpUv8OrxvkRfbz4-XN81959vP11f3TeGt_3cqJFyRggIbakwRjCjBWG7HbEgBmYGq8FqajnTRhDNuAVLB0oGK9jY26Hll-jt2Zty_LZAmWVwxYD3aoK4FMl62hMh-EArSs-oybGUDFam7ILKq6REnqqRx_qS5Kkaea6mZt486hcdYPyX-NtFBT6cAaifrKvIshgHk4HR5bpAOUb3H_1v2NSiHg</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Casciaro, Marco</creator><creator>Vincelli, Donatella</creator><creator>Ferraro, Maria</creator><creator>Mirabile, Giuseppe</creator><creator>Pace, Elisabetta</creator><creator>Martino, Bruno</creator><creator>Tonacci, Alessandro</creator><creator>Gangemi, Sebastiano</creator><creator>Pioggia, Giovanni</creator><creator>Allegra, Alessandro</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6156-8239</orcidid></search><sort><creationdate>202307</creationdate><title>The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature</title><author>Casciaro, Marco ; Vincelli, Donatella ; Ferraro, Maria ; Mirabile, Giuseppe ; Pace, Elisabetta ; Martino, Bruno ; Tonacci, Alessandro ; Gangemi, Sebastiano ; Pioggia, Giovanni ; Allegra, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-ad13200e5bf15cc52cb502770fe592c9fbefb1f32bc50b23fef19109f52d8f943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alarmins</topic><topic>High-mobility group box-1</topic><topic>HMGB1 Protein</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Monoclonal gammopathies of uncertain significance</topic><topic>Monoclonal Gammopathy of Undetermined Significance</topic><topic>Multiple Myeloma</topic><topic>Paraproteinemias</topic><topic>Psoriasin</topic><topic>RAGE</topic><topic>S100 Calcium Binding Protein A7</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casciaro, Marco</creatorcontrib><creatorcontrib>Vincelli, Donatella</creatorcontrib><creatorcontrib>Ferraro, Maria</creatorcontrib><creatorcontrib>Mirabile, Giuseppe</creatorcontrib><creatorcontrib>Pace, Elisabetta</creatorcontrib><creatorcontrib>Martino, Bruno</creatorcontrib><creatorcontrib>Tonacci, Alessandro</creatorcontrib><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><creatorcontrib>Pioggia, Giovanni</creatorcontrib><creatorcontrib>Allegra, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Casciaro, Marco</au><au>Vincelli, Donatella</au><au>Ferraro, Maria</au><au>Mirabile, Giuseppe</au><au>Pace, Elisabetta</au><au>Martino, Bruno</au><au>Tonacci, Alessandro</au><au>Gangemi, Sebastiano</au><au>Pioggia, Giovanni</au><au>Allegra, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2023-07</date><risdate>2023</risdate><volume>247</volume><spage>154562</spage><epage>154562</epage><pages>154562-154562</pages><artnum>154562</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Multiple myeloma (MM) is a plasma cells neoplasm which is often preceded by a preneoplastic condition called monoclonal gammopathy of unknown significance (MGUS). A protein called High-mobility group box-1 (HMGB-1) controls transcription and genomic stability. Both pro- and anti-tumor properties of HMGB1 have been described during tumor growth. The S100 protein family includes a protein known as psoriasin. Poorer prognosis and survival were linked to higher psoriasin expression in cancer patients. The goal of the current investigation was to compare the plasma levels of HMGB-1 and psoriasin in patients with MM and MGUS significance, as well as in a group of healthy controls. According to our research, patients with MGUS have higher HMGHB-1 concentrations than healthy controls (846.7 ± 287.6 pg/ml vs. 176.9 ± 204.8 pg/ml for controls, p &lt; 0.001). Similarly, we found a huge difference in HMGB-1 levels for MM patients with respect to controls (928.0 ± 551.4 pg/ml vs. 176.9 ± 204.8 pg/ml; p = 0.001). No difference was found as for the Psoriasin levels in the three groups considered. Additionally, we tried to evaluate the knowledge already present in the literature about putative mechanisms of action for these molecules in the onset and development of these disorders.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>37216746</pmid><doi>10.1016/j.prp.2023.154562</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6156-8239</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0344-0338
ispartof Pathology, research and practice, 2023-07, Vol.247, p.154562-154562, Article 154562
issn 0344-0338
1618-0631
language eng
recordid cdi_proquest_miscellaneous_2818055391
source ScienceDirect Freedom Collection
subjects Alarmins
High-mobility group box-1
HMGB1 Protein
Humans
Inflammation
Monoclonal gammopathies of uncertain significance
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Paraproteinemias
Psoriasin
RAGE
S100 Calcium Binding Protein A7
Tumorigenesis
title The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T19%3A34%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20High-mobility%20group%20box-1%20and%20Psoriasin%20in%20multiple%20myeloma:%20Analysis%20of%20a%20population%20affected%20by%20monoclonal%20gammopathies%20and%20review%20of%20the%20literature&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Casciaro,%20Marco&rft.date=2023-07&rft.volume=247&rft.spage=154562&rft.epage=154562&rft.pages=154562-154562&rft.artnum=154562&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/j.prp.2023.154562&rft_dat=%3Cproquest_cross%3E2818055391%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c348t-ad13200e5bf15cc52cb502770fe592c9fbefb1f32bc50b23fef19109f52d8f943%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2818055391&rft_id=info:pmid/37216746&rfr_iscdi=true