Role of perfusion index and plethysmography variability index for predicting outcomes in neonatal sepsis

Aim (i) To compare perfusion index (PI) and plethysmography variability index (PVI) between neonates with proven or probable sepsis versus no‐sepsis, (ii) to examine an association of PI and PVI with in‐hospital mortality. Methods We enrolled neonates with clinically presumed sepsis. Culture‐proven...

Full description

Saved in:
Bibliographic Details
Published in:Acta Paediatrica 2023-09, Vol.112 (9), p.1884-1891
Main Authors: Saini, Shiv Sajan, Shrivastav, Amit Kumar, Sundaram, Venkataseshan, Dutta, Sourabh, Kumar, Praveen
Format: Article
Language:English
Subjects:
microcirculation
Mortality
Neonates
Perfusion
PVI
Sepsis
Citations: Items that this one cites
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim (i) To compare perfusion index (PI) and plethysmography variability index (PVI) between neonates with proven or probable sepsis versus no‐sepsis, (ii) to examine an association of PI and PVI with in‐hospital mortality. Methods We enrolled neonates with clinically presumed sepsis. Culture‐proven or probable sepsis were categorised as ‘cases’ and no‐sepsis as ‘controls’. PI and PVI were recorded hourly for 120 h and averaged in 20‐time epochs (0–6 h to 115–120 h). Results We analysed 148 neonates with sepsis (proven sepsis = 77, probable sepsis = 71) and 126 with no‐sepsis. Neonates with proven/probable sepsis and no‐sepsis had comparable PI and PVI values. Among 148 neonates with sepsis, 43 (29%) died. Non‐survivors had significantly lower PI values than survivors (mean difference 0.21 [95% CI 0.14–0.29], p‐value
ISSN:0803-5253
1651-2227
DOI:10.1111/apa.16856