Efficacy and safety of Banxia-Houpo-Tang (Banha-Hubak-Tang) for depression: A systematic review and meta-analysis

and purpose: Banxia-Houpo-Tang (Banha-Hubak-Tang, BHT) is an East Asian traditional herbal medicine used for treating depression. Hence, this review aimed to provide reliable evidence on the efficacy and safety of BHT for depression. Overall, 15 electronic databases were searched until July 31, 2022...

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Published in:Complementary therapies in clinical practice 2023-08, Vol.52, p.101769-101769, Article 101769
Main Authors: Kim, Da-Woon, Kwon, Hye-Won, Kim, Sang-Ho
Format: Article
Language:English
Subjects:
Antidepressive Agents - adverse effects
Banxia-Houpo-Tang
Combined Modality Therapy
Depression
Depression - therapy
Herbal medicine
Humans
Meta-analysis
Pinellia
Systematic review
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Summary:and purpose: Banxia-Houpo-Tang (Banha-Hubak-Tang, BHT) is an East Asian traditional herbal medicine used for treating depression. Hence, this review aimed to provide reliable evidence on the efficacy and safety of BHT for depression. Overall, 15 electronic databases were searched until July 31, 2022, and randomized controlled trials (RCTs) of BHT for depression were reviewed. The cochrane risk of bias tool version 2.0 was used for quality assessment. A meta-analysis was conducted to evaluate the efficacy and safety of BHT for depression. Fifteen RCTs (1,714 participants) were included. The pooled results suggested that the efficacy of BHT alone (standardized mean difference [SMD], −0.39; 95% confidence interval [CI], −0.79 to 0.00; P = 0.05) was similar to that of antidepressants alone in terms of the Hamilton depression scale (HAMD) scores. Their combination led to a more significant improvement in HAMD scores (SMD, −0.91; 95% CI, −1.21 to 0.60; P 
ISSN:1744-3881
1873-6947
DOI:10.1016/j.ctcp.2023.101769