MYC‐induced cytidine metabolism regulates survival and drug resistance via cGas‐STING pathway in mantle cell lymphoma

Lymphocyte proliferation and tumourigenesis are dependent on nucleotide synthesis to support DNA, RNA and phospholipid synthesis. Here, we identified that reprogramming of nucleotide metabolism as an important factor divides mantle cell lymphoma (MCL) into two groups with different transcriptional s...

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Bibliographic Details
Published in:British journal of haematology 2023-08, Vol.202 (3), p.550-565
Main Authors: Liang, Jin‐Hua, Ren, Yi‐Min, Du, Kai‐Xin, Gao, Rui, Duan, Zi‐Wen, Guo, Jing‐Ran, Xing, Tong‐Yao, Wang, Wei‐Ting, Wang, Li, Wang, Yan, Wang, Rong, Li, Jian‐Yong, Xu, Wei
Format: Article
Language:English
Subjects:
Adult
Clinical trials
CRISPR
CTP
Cytidine - therapeutic use
cytidine metabolism
Cytidine triphosphate
DNA biosynthesis
DNA damage
Drug metabolism
Drug resistance
Drug Resistance, Neoplasm
dsDNA‐cGAS‐STING pathway
Hematology
Humans
ibrutinib resistance
Lymphocytes
Lymphoma
Lymphoma, Mantle-Cell - drug therapy
Mantle cell lymphoma
Medical prognosis
Metabolism
Myc protein
Nucleotides - therapeutic use
Nucleotidyltransferases
p53 Protein
Phospholipids
Prognosis
Signal transduction
TP53 aberrancy
Transcription
Tumorigenesis
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Summary:Lymphocyte proliferation and tumourigenesis are dependent on nucleotide synthesis to support DNA, RNA and phospholipid synthesis. Here, we identified that reprogramming of nucleotide metabolism as an important factor divides mantle cell lymphoma (MCL) into two groups with different transcriptional signalling pathways and varying prognoses. We establish a nucleotide metabolism‐related prognostic model that includes six genes with different regression coefficients, which significantly predicts prognosis for MCL patients (p 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18878