Endocrine-disrupting chemicals and autoimmune diseases

Endocrine-disrupting chemicals (EDCs) widely exist in people's production and life which have great potential to damage human and animal health. Over the past few decades, growing attention has been paid to the impact of EDCs on human health, as well as immune system. So far, researchers have p...

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Bibliographic Details
Published in:Environmental research 2023-08, Vol.231 (Pt 2), p.116222-116222, Article 116222
Main Authors: Huang, Rong-Gui, Li, Xian-Bao, Wang, Yi-Yu, Wu, Hong, Li, Kai-Di, Jin, Xue, Du, Yu-Jie, Wang, Hua, Qian, Fang-Yi, Li, Bao-Zhu
Format: Article
Language:English
Subjects:
Autoimmune diseases
Endocrine environmental disruptors
Inflammatory bowel disease
Rheumatoid arthritis
System lupus erythematosus
Type 1 diabetes
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Summary:Endocrine-disrupting chemicals (EDCs) widely exist in people's production and life which have great potential to damage human and animal health. Over the past few decades, growing attention has been paid to the impact of EDCs on human health, as well as immune system. So far, researchers have proved that EDCs (such as bisphenol A (BPA), phthalate, tetrachlorodibenzodioxin (TCDD), etc.) affect human immune function and promotes the occurrence and development of autoimmune diseases (ADs). Therefore, in order to better understand how EDCs affect ADs, we summarized the current knowledge about the impact of EDCs on ADs, and elaborated the potential mechanism of the impact of EDCs on ADs in this review. •Endocrine disruptors (EDCs) are a new environmental factor, which has gradually attracted people's attention.•EDCs is association with autoimmune diseases (ADs). Most EDCs might be potential risk factors for ADs.•Exposure to EDCs will lead to endocrine system disorder, imbalance of immune system, inflammation and DNA damage.
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2023.116222