Controlled Assembly of Protein-Nanoparticle Composites through Protein Surface Recognition

Controlled assembly of protein–nanoparticle composites through complementary protein surface recognition is demonstrated. Interaction of an unstable protein (chymotrypsin) with a gold nanoparticle results in close interparticle spacing, while a stable protein (cytochrome C) that retains its structur...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2005-03, Vol.17 (5), p.617-621
Main Authors: Srivastava, S., Verma, A., Frankamp, B. L., Rotello, V. M.
Format: Article
Language:English
Subjects:
Assembly
gold
Nanoparticles
Nanoparticles, gold
Proteins
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Summary:Controlled assembly of protein–nanoparticle composites through complementary protein surface recognition is demonstrated. Interaction of an unstable protein (chymotrypsin) with a gold nanoparticle results in close interparticle spacing, while a stable protein (cytochrome C) that retains its structure upon binding produces a hybrid material with a larger interparticle distance (see Figure).
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200400776