Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure

Goal: Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based o...

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Bibliographic Details
Published in:IEEE open journal of engineering in medicine and biology 2023-01, Vol.4, p.96-101
Main Authors: Yang, Jason, Acharya, Deepshikha, Scammon, William B., Schmitt, Samantha, Crane, Emily C., Smith, Matthew A., Kainerstorfer, Jana M.
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Blood flow
Cerebral autoregulation
Cerebral blood flow
cerebral hemodynamics
cerebrovascular impedance
Detectors
diffuse correlation spectroscopy
Frequency measurement
Impedance
Impedance measurement
Impedance method
Infrared spectra
Infrared spectroscopy
Near infrared radiation
near-infrared spectroscopy
Optical fiber devices
Optics
Perfusion
Pressure
Signal to noise ratio
Vasoactive agents
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Summary:Goal: Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based on the spectral content of cerebral blood flow and volume at the cardiac frequency, measured with diffuse optical methods. Methods: In three non-human primates, we modulated cerebral perfusion pressure beyond the limits of autoregulation. Cerebral blood flow and volume were measured with diffuse correlation spectroscopy and near-infrared spectroscopy, respectively. Results: We show that impedance can be used to identify the lower and upper limits of autoregulation. Conclusions: This impedance method may be an alternative method to measure autoregulation and a way of assessing cerebral health non-invasively at the clinical bedside.
ISSN:2644-1276
2644-1276
DOI:10.1109/OJEMB.2023.3236267