A brief history of clozapine in China with a look forward

Clozapine was first manufactured in China in 1976. Clozapine is currently used not only for treatment-refractory schizophrenia (TRS), but also continues to be used in the treatment of patients with non-TRS and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic the...

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Bibliographic Details
Published in:Schizophrenia research 2024-06, Vol.268, p.25-28
Main Authors: Ruan, Can-Jun, Wang, Chuan-Yue, Zang, Yan-Nan, Liu, Chen-Geng, Dong, Fang, Li, An-Ning, Wan, Zhou, Guo, Wei, Wang, Gang
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Antipsychotic Agents - history
Asian continental ancestry group
China
Clozapine - adverse effects
Clozapine - history
Clozapine - therapeutic use
Clozapine/toxicity
Drug interaction
History, 20th Century
History, 21st Century
Humans
Pneumonia
Schizophrenia - drug therapy
Schizophrenia - history
Schizophrenia, Treatment-Resistant - drug therapy
Schizophrenia, Treatment-Resistant - history
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Summary:Clozapine was first manufactured in China in 1976. Clozapine is currently used not only for treatment-refractory schizophrenia (TRS), but also continues to be used in the treatment of patients with non-TRS and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic therapy and in combination with other drugs. There is need for studies in China using various titrations and assessing their risk for myocarditis and aspiration pneumonia. The Chinese clozapine package insert will also greatly benefit from these changes.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2023.03.048