Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine‐based tripeptides

Peptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxic...

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Published in:Journal of biochemical and molecular toxicology 2023-08, Vol.37 (8), p.e23388-n/a
Main Authors: Çalışkan, Eray, Kaplan, Alpaslan, Şekerci, Güldeniz, Çapan, İrfan, Tekin, Suat, Erkan, Sultan, Koran, Kenan, Sandal, Süleyman, Görgülü, Ahmet O.
Format: Article
Language:English
Subjects:
ADME
Amino acids
Bioassays
Biological activity
Biological research
Cancer
Cell viability
Colon cancer
Comet assay
Cytotoxicity
Damage
DNA damage
Docking
molecular docking
Peptides
Toxicity
Triazine
Tumor cell lines
Tyrosine
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Summary:Peptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxicity properties of all compounds against human cancer cell lines (MCF‐7), ovarian (A2780), prostate (PC‐3), and colon cancer cell lines (Caco‐2) were determined by the 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide assay method, and % cell viability and logIC50 values of the compounds were calculated. Significant decreases in cell viability were observed in all cells (p 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23388