Opportunistic coeliac disease screening in undifferentiated presentations to paediatric acute care

• Published in: Journal of paediatrics and child health 2023-08, Vol.59 (8), p.992-997
• Main Authors: Pathmanandavel, Karrnan, Wong, Melanie, Williams, Emma, Stormon, Michael, Nogajski, Rebecca, Williams, Andrew
• Format: Article
• Language: English
• Subjects: Autoantibodies; Biopsy; Celiac disease; Celiac Disease - diagnosis; Child; emergency department; Emergency medical care; Gliadin; Humans; Immunoglobulin A; Immunoglobulin G; Medical screening; Pediatrics; potential coeliac disease; Sensitivity and Specificity; targeted screening; Transglutaminases
• ISSN: 1034-4810; 1440-1754
• DOI: 10.1111/jpc.16446

Aim Coeliac disease (CD) can remain undiagnosed due to absent/atypical symptoms. We evaluated screening for CD in undifferentiated paediatric patients in the emergency department (ED). Methods Subjects were all patients presenting to a children's hospital ED during the study period who had blood taken. Plasma remaining after routine care was tested for tissue transglutaminase IgA (tTG IgA) and deamidated gliadin IgG (DGP IgG) antibodies. Patients with positive results were counselled and offered confirmatory testing, then gastroenterology review if warranted. Results An initial positive result for either DGP IgG or tTG IgA was found in 4.2% (44/1055). There was a normalisation of 76% (19/25) of positive DGP IgG and 44% (4/9) of tTG IgA results on repeat testing, which was not available in 27% (12/44). The prevalence of biopsy‐confirmed CD was 0.7% (7/1055), including two new diagnoses and five subjects with known CD. Three likely cases could not be confirmed. All confirmed and likely cases were >10 years old. In children >10 years old, the prevalence of either biopsy‐confirmed or likely CD was 3.3% (10/302). A family history of CD, growth concerns, recurrent abdominal pain and lethargy were associated with persistence of positive tests. Conclusion Opportunistic testing for CD in ED requires further investigation as a CD screening strategy. Our results suggest optimal screening in this setting should be by initially testing for tTG IgA and total IgA in children >10 years old (minimising transiently positive tests). Transiently positive coeliac antibodies may also warrant further investigation as a predictor of future CD.