Convolutional neural network-based evaluation of chemical maps obtained by fast Raman imaging for prediction of tablet dissolution profiles

• Published in: International journal of pharmaceutics 2023-06, Vol.640, p.123001-123001, Article 123001
• Main Authors: Galata, Dorián László, Zsiros, Boldizsár, Knyihár, Gábor, Péterfi, Orsolya, Mészáros, Lilla Alexandra, Ronkay, Ferenc, Nagy, Brigitta, Szabó, Edina, Nagy, Zsombor Kristóf, Farkas, Attila
• Format: Article
• Language: English
• Subjects: Convolutional neural network; Deep learning; Delayed-Action Preparations - chemistry; Dissolution prediction; Fast Raman imaging; Hypromellose Derivatives; Methylcellulose - chemistry; Neural Networks, Computer; Process analytical technology; Solubility; Sustained release tablets; Tablets - chemistry
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2023.123001

[Display omitted] In this work, the capabilities of a state-of-the-art fast Raman imaging apparatus are exploited to gain information about the concentration and particle size of hydroxypropyl methylcellulose (HPMC) in sustained release tablets. The extracted information is utilized to predict the in vitro dissolution profile of the tablets. For the first time, convolutional neural networks (CNNs) are used for the processing of the chemical images of HPMC distribution and to directly predict the dissolution profile based on the image. This new method is compared to wavelet analysis, which gives a quantification of the texture of HPMC distribution, carrying information regarding both concentration and particle size. A total of 112 training and 32 validation tablets were used, when a CNN was used to characterize the particle size of HPMC, the dissolution profile of the validation tablets was predicted with an average f2 similarity value of 62.95. Direct prediction based on the image had an f2 value of 54.2, this demonstrates that the CNN is capable of recognizing the patterns in the data on its own. The presented methods can facilitate a better understanding of the manufacturing processes, as detailed information becomes available with fast measurements.