Mesenchymal stromal cells and CAR‐T cells in regenerative medicine: The homing procedure and their effective parameters

Mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)‐T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molec...

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Bibliographic Details
Published in:European journal of haematology 2024-02, Vol.112 (2), p.153-173
Main Authors: Kolahi Azar, Hanieh, Imanpour, Aylar, Rezaee, Hanieh, Ezzatifar, Fatemeh, Zarei‐Behjani, Zeinab, Rostami, Mohammadreza, Azami, Mahmoud, Behestizadeh, Nima, Rezaei, Nima
Format: Article
Language:English
Subjects:
Cancer therapies
CAR‐T cells
Cell culture
cell homing
Cell therapy
Chemokines
Chimeric antigen receptors
Humans
Immunomodulation
Immunotherapy, Adoptive - methods
Lymphocytes T
Mesenchymal Stem Cells
mesenchymal stromal cells
Neoplasms - therapy
Regenerative medicine
Regenerative Medicine - methods
Solid tumors
Stromal cells
T-Lymphocytes
Tumor Microenvironment
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Summary:Mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)‐T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR‐T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non‐systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR‐T cells for cancer treatment were discussed.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.14014