Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri

Two new cembranoids, namely sarcoboettgerols D and E, together with four known related ones, have been isolated from the soft coral Sarcophyton boettgeri collected from Weizhou Island in the South China Sea. Their structures including absolute configurations were elucidated by extensive spectroscopi...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-07, Vol.20 (7), p.e202300662-n/a
Main Authors: Yu, Jia‐Dong, Su, Ming‐Zhi, Gu, Yu‐Cheng, Yu, Dan‐Dan, Yao, Li‐Gong, Shen, Shou‐Mao, Guo, Yue‐Wei, Wang, Hong
Format: Article
Language:English
Subjects:
Animals
Anthozoa - anatomy & histology
Anthozoa - chemistry
Anthozoa - metabolism
Antibacterial activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Bioassays
biological activities
Cell Line, Tumor
cembranoids
Circular dichroism
Cytotoxicity
Density functional theory
Dichroism
Diterpenes - chemistry
Diterpenes - pharmacology
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
NMR
Nuclear magnetic resonance
Quantum mechanics
Sarcophyton
Sarcophyton boettgeri
soft coral
stereochemistry
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Summary:Two new cembranoids, namely sarcoboettgerols D and E, together with four known related ones, have been isolated from the soft coral Sarcophyton boettgeri collected from Weizhou Island in the South China Sea. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance methods, time‐dependent density functional theory‐electronic circular dichroism calculations, as well as comparison with the reported data in the literature. A plausible biogenetic relationship of four cembranoids was proposed. In bioassays, sarcomililatin B exhibited cytotoxic activity against H1299 cell (IC50=35.0 μM), whereas sarcomililatin B and sarcomililatin A displayed moderate antibacterial activities (MIC 17.4–34.8 μg/mL).
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300662