Profiling the microbiome of oral and genital mucosal surfaces in Behçet's disease

Almost 90% of Behçet's patients present with oral and/or genital ulcers which influence the disease outcome. We hypothesised that the dysregulation of the oral and genital microbiome, coupled with dysregulation of the immune response, contributes to the aetiopathogenesis of Behçet's Diseas...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2023-08, Vol.253, p.109654-109654, Article 109654
Main Authors: Ogunkolade, William, Senusi, Amal A., Desai, Pareen, Sacoor, Sarah, Bibi, Azimoon, Gokani, Bindi, Sandionigi, Anna, Fortune, Farida
Format: Article
Language:English
Subjects:
Autoinflammatory conditions
Bacteria
Behcet Syndrome - complications
Behçet's disease activity
Colchicine - therapeutic use
Female
Genitalia
Humans
Immunosuppressive medication
Male
Microbiota
Mucous Membrane
Orogenital mucosal microbiome
Orogenital mucosal ulcers
Triorasol mouthwash
Ulcer - drug therapy
Ulcer - etiology
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Summary:Almost 90% of Behçet's patients present with oral and/or genital ulcers which influence the disease outcome. We hypothesised that the dysregulation of the oral and genital microbiome, coupled with dysregulation of the immune response, contributes to the aetiopathogenesis of Behçet's Disease (BD) and drives disease activation. 152 BD patient samples; 70 matched oral and genital samples plus 12 unmatched samples (Female: Male, 58:12; mean age, 42 ± 13.9: 39.3 ± 10.3) to profile microbial community high-throughput sequencing of the microbiome using 16 s rRNA sequencing targeting the V1/V2 and V3/V4 hyper variable regions were used and results reviewed in relation to disease severity, Work and Social Adjustment Scale (WSAS) outcomes and medication. Alpha and beta diversity were significantly decreased in genital compared to oral samples; p value
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2023.109654