Quantification of Cerebral Glucose Concentrations via Detection of the H1-α-Glucose Peak in 1 H MRS at 7 T

• Published in: Journal of magnetic resonance imaging 2024-02, Vol.59 (2), p.661-672
• Main Authors: Kuribayashi, Hideto, Urushibata, Yuta, Imai, Hirohiko, Ahn, Sinyeob, Seethamraju, Ravi Teja, Isa, Tadashi, Okada, Tomohisa
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain - metabolism; Humans; Magnetic Resonance Spectroscopy - methods; Prospective Studies; Retrospective Studies; Signal-To-Noise Ratio; Water
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.28834

Sensitive detection and quantification of cerebral glucose is desired. To quantify cerebral glucose by detecting the H1-α-glucose peak at 5.23 ppm in H magnetic resonance spectroscopy at 7 T. Prospective. Twenty-eight non-fasted healthy subjects (aged 20-28 years). Short echo time stimulated echo acquisition mode (short-TE STEAM) and semi-localized by adiabatic selective refocusing (semi-LASER) at 7 T. Single voxel spectra were obtained from the posterior cingulate cortex (27-mL) using a 32-channel head coil. The H1-α-glucose peak in the spectrum with retrospective removal of the residual water peak was fitted using LCModel with a glucose basis set of only the H1-α-glucose peak. Conventional spectral analysis was performed with a glucose basis set of a full spectral pattern of glucose, also. Fitting precision was evaluated with Cramér-Rao lower bounds (CRLBs). The repeatability of glucose quantification via the semi-LASER sequence was tested. Paired or Welch's t-test were used for normally distributed values. A P value of