Pneumococcal serotypes and antibiotic resistance in healthy carriage children after introduction of PCV13 in Lima, Peru

•The frequency of pneumococcal nasopharyngeal carriage has decreased after PCV13 introduction.•The frequency of PCV13 serotypes has decreased after PCV13 introduction compared to the pre-PCV7 period.•Antimicrobial resistance in Streptococcus pneumoniae has increased after PCV13 compared to the pre-P...

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Bibliographic Details
Published in:Vaccine 2023-06, Vol.41 (28), p.4106-4113
Main Authors: Gonzales, Brayan E., Mercado, Erik H., Castillo-Tokumori, Franco, Montero, Andrea E., Luna-Muschi, Alessandra, Marcelo-Ragas, Madhelli, Campos, Francisco, Chaparro, Eduardo, Del Águila, Olguita, Castillo, María E., Saenz, Andrés, Reyes, Isabel, Hernandez, Roger, Ochoa, Theresa J.
Format: Article
Language:English
Subjects:
Anti-Infective Agents
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Azithromycin
Caregivers
Carrier State - microbiology
Child
Children
Children & youth
Cross-Sectional Studies
Diffusion rate
Drug resistance
Hospitals
Humans
Illnesses
Immunization
Infant
Laboratories
Meningitis
Minimum inhibitory concentration
Multivariate analysis
Nasopharyngeal carriers
Nasopharynx - microbiology
Penicillin
Penicillin Resistance
Peru - epidemiology
Pneumococcal conjugate vaccine
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines
Pneumonia
Respiratory diseases
Sepsis
Serogroup
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - genetics
Vaccines
Vaccines, Conjugate
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Summary:•The frequency of pneumococcal nasopharyngeal carriage has decreased after PCV13 introduction.•The frequency of PCV13 serotypes has decreased after PCV13 introduction compared to the pre-PCV7 period.•Antimicrobial resistance in Streptococcus pneumoniae has increased after PCV13 compared to the pre-PCV7 period. To determinate the frequency of Streptococcus pneumoniae nasopharyngeal carriers, serotypes and antimicrobial resistance in healthy children in Lima, Peru, post-PCV13 introduction and to compare the results with a similar study conducted between 2006 and 2008 before PCV7 introduction (pre-PCV7). A cross-sectional multicenter study was conducted between January 2018 and August 2019 in 1000 healthy children under two years of age. We use standard microbiological methods to determinate S. pneumoniae from nasopharyngeal swab, Kirby Bauer and minimum inhibitory concentration methods to determinate antimicrobial susceptibility and whole genomic sequencing to determinate pneumococcal serotypes. The pneumococcal carriage rate was 20.8 % vs. 31.1 % in pre-PCV7 (p 
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2023.05.042