Use of ecarin chromogenic assay during bivalirudin anticoagulation in adult extracorporeal membrane oxygenation

•The aPTT lacks specificity for bivalirudin and may be unreliable during ECMO.•Ecarin chromogenic assay (ECA) was evaluated for bivalirudin monitoring during ECMO.•Bivalirudin ECA was most commonly obtained during suspected aPTT unresponsiveness.•The ECA may have greatest utility in patients on ECMO...

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Published in:Thrombosis research 2023-08, Vol.228, p.42-45
Main Authors: Krauter, Abby K., Nei, Scott D., Seelhammer, Troy G., Bohman, J. Kyle, Wieruszewski, Patrick M.
Format: Article
Language:English
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Summary:•The aPTT lacks specificity for bivalirudin and may be unreliable during ECMO.•Ecarin chromogenic assay (ECA) was evaluated for bivalirudin monitoring during ECMO.•Bivalirudin ECA was most commonly obtained during suspected aPTT unresponsiveness.•The ECA may have greatest utility in patients on ECMO with acute thrombosis.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2023.05.022