Unfolding cognitive decline mechanisms

The number of neural stem cells in the brain decreases with age, which in the dentate gyrus of older mice is associated with a lower SIRT7-mediated mitochondrial unfolded protein response and reduced neural stem cell maintenance and neurogenesis.

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Bibliographic Details
Published in:Nature reviews. Neuroscience 2023-07, Vol.24 (7), p.394-394
Main Author: Lewis, Sian
Format: Article
Language:English
Subjects:
631/378/1595/1554
631/378/2611
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain stem
Cognitive ability
Dentate gyrus
Neural stem cells
Neurobiology
Neurogenesis
Neurosciences
Protein folding
Research Highlight
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Description
Summary:The number of neural stem cells in the brain decreases with age, which in the dentate gyrus of older mice is associated with a lower SIRT7-mediated mitochondrial unfolded protein response and reduced neural stem cell maintenance and neurogenesis.
ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/s41583-023-00715-8