Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery

•Ultradeformable vesicles are an advanced version of conventional lipid vesicles having extensive flexibility.•Edge activators are a chief component for improving flexibility and deformability of lipid vesicles.•Ultradeformable vesicles can effectively cross the physiological barriers of the eye owi...

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Bibliographic Details
Published in:Drug discovery today 2023-08, Vol.28 (8), p.103647-103647, Article 103647
Main Authors: Srivastava, Vaibhavi, Singh, Vivek, Kumar Khatri, Dharmendra, Kumar Mehra, Neelesh
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Drug Carriers - pharmacology
Drug Delivery Systems
elastic vesicles
Excipients - pharmacology
extravesicles
Eye
Liposomes
ocular drug delivery
ophthalmic delivery
Skin
ultradeformable
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Summary:•Ultradeformable vesicles are an advanced version of conventional lipid vesicles having extensive flexibility.•Edge activators are a chief component for improving flexibility and deformability of lipid vesicles.•Ultradeformable vesicles can effectively cross the physiological barriers of the eye owing to its flexibility and elasticity.•Elastic vesicles are vigorously exploring by ophthalmologists to exploit it for effective ocular drug delivery. Ocular drug delivery is enigmatic on account of various physiological precorneal barriers that ultimately hinder efficient drug penetration and corneal absorption. Ultradeformable vesicles embody non-ionic surfactants, edge activators and vesicular builders that provide enormous elasticity and deformability. The elastic vesicles can cross the ocular barriers owing to their peculiar squeezability and distorting ability and, thus, establish an infallible shot for ocular delivery. This review provides an overview of the recent advancements and updates of elastic vesicles as effective ocular drug delivery vehicles.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2023.103647