Is elevated ENA-78 serum level a link between obstructive sleep apnea and atherosclerosis?

• Published in: Respiratory physiology & neurobiology 2023-08, Vol.314, p.104088-104088, Article 104088
• Main Authors: Nahorecki, Artur, Szuba, Andrzej, Martynowicz, Helena, Szponder, Mateusz, Janczak, Dariusz, Postrzech-Adamczyk, Katarzyna
• Format: Article
• Language: English
• Subjects: Atherosclerosis; Atherosclerosis - complications; Carotid artery stenosis; Carotid Stenosis - complications; Cytokines; Humans; Hypoxia; Hypoxia - complications; Inflammation; Obstructive sleep apnea; Risk Factors; Sleep Apnea, Obstructive
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2023.104088

Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, inflammation, and oxidative stress. This study compared serum levels of different factors in patients with carotid artery stenosis and with or without coexisting OSA. It also aimed to identify a molecule that may be crucial for the inflammatory process correlated with intermittent hypoxia. Sixty-eight subjects scheduled for surgical treatment of carotid artery stenosis were enrolled. Polygraphy was performed the night before the surgery. Morning levels of proinflammatory cytokines and chemotactic and angiogenic factors were measured. The most profound differences between the groups were found for ENA-78 serum concentration. However, as many factors could affect the results, further studies are needed to investigate the role of ENA-78 in atherosclerosis in patients suffering from OSA. •Prevalence of obstructive sleep apnea in patients with atherosclerotic carotid artery stenosis is high.•Serum levels of proinflammatory cytokines, chemotactic agents and angiogenic factors did not differ significantly between patients with and without obstructive sleep apnea.•Some variation for serum levels of epithelial neutrophil-activating protein-78 were observed between patients with and without obstructive sleep apnea.