Construction and formulation optimization of prothioconazole nanoemulsions for the control of Fusarium graminearum: Enhancing activity and reducing toxicity

In this study, the optimal emulsifier for prothioconazole nanoemulsions was initially screened based on appearance, microscopic observation, mean droplet size and polydispersity index (PDI). In addition, the BoxBehnken design method is adopted, and the optimal formula is screened with an emulsificat...

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Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-07, Vol.227, p.113379-113379, Article 113379
Main Authors: Lv, Ze, Meng, Xiaohan, Sun, Shaoyang, Jiang, Tianzhen, Li, Yan, Feng, Jianguo
Format: Article
Language:English
Subjects:
acute toxicity
Biosafety
Box-Behnken Design
contact angle
Danio rerio
droplet size
emulsifiers
emulsifying
Fusarium graminearum
manufacturing
microscopy
Nanoemulsions
pesticides
plant protection
Prothioconazole
seed germination
solvents
sustainable development
wheat
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Summary:In this study, the optimal emulsifier for prothioconazole nanoemulsions was initially screened based on appearance, microscopic observation, mean droplet size and polydispersity index (PDI). In addition, the BoxBehnken design method is adopted, and the optimal formula is screened with an emulsification time, emulsifier content, and solvent content as a single factor. On this basis, the nanoemulsion meets FAO standards for various indicators. The contact angle of droplets on wheat leaves was significantly reduced. This nanoemulsion also showed good inhibitory activity against Fusarium graminearum (EC50 =1.94 mg L−1), low acute toxicity to zebrafish (LC50 =26.35 mg L−1) and good biosafety to BEAS-2B cells. The nanoemulsion reduced the adverse effects of pesticide on wheat seed germination and growth. This study can help promote the design and manufacture of stable, efficient and safe agricultural nanoemulsions, and is expected to benefit the sustainable development of green plant protection. [Display omitted] •Highly efficient and stable Prot@NE was prepared by low-energy emulsification method.•BBD screens Prot@NE formulations for low organic solvent content and high stability.•Prot@NE has high antifungal activity and low toxicity to zebrafish and cells.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2023.113379