ALK-Negative Inflammatory Myofibroblastic Tumor: A Challenging Case in a Premature Newborn

Inflammatory myofibroblastic tumors (IMT) are rare borderline tumors with a variable histological appearance that may mimic multiple mesenchymal tumors. We present a rare case of a challenging abdominal mass discovered in a premature newborn. The histopathology showed a bland myofibroblastic prolife...

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Bibliographic Details
Published in:Journal of neonatal-perinatal medicine 2023-01, Vol.16 (2), p.355-359
Main Authors: Regaieg, C., Triki, M., Cheikrouhou, T., Thabet, A.B., Charfi, S., Dhaou, M.B., Boudawara, T., Hamed, A.B., Hmida, N.
Format: Article
Language:English
Subjects:
Genetic Testing
Granuloma, Plasma Cell - diagnosis
Granuloma, Plasma Cell - genetics
Granuloma, Plasma Cell - surgery
Humans
Infant, Newborn
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Summary:Inflammatory myofibroblastic tumors (IMT) are rare borderline tumors with a variable histological appearance that may mimic multiple mesenchymal tumors. We present a rare case of a challenging abdominal mass discovered in a premature newborn. The histopathology showed a bland myofibroblastic proliferation associated with an inflammatory infiltrate that was positive for smooth muscle actin and desmin but negative for anaplastic lymphoma kinase (ALK) protein. The diagnosis of an ALK-negative IMT was established. The tumor was partially resected. After six months of follow-up, the residual tumor remained stable, and the patient was asymptomatic. The correct diagnosis and subsequent treatment of ALK-negative IMT require appropriate histopathological, immunohistochemical, and sometimes genetic examination. Further research has to be conducted to help clinicians make an appropriate treatment plan.
ISSN:1934-5798
1878-4429
DOI:10.3233/NPM-230007