Nanocrystals in cosmetics and cosmeceuticals by topical delivery

The main issues with local delivery of cosmetics are their high sensitivity and limited drug loading of active pharmaceutical ingredient. Nanocrystal technology offers consumers cutting-edge and effective products and exhibits enormous development potential in the beauty business as a new delivery m...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-07, Vol.227, p.113385-113385, Article 113385
Main Authors: Liu, Yi, Zhao, Jingru, Chen, Jing, Miao, Xiaoqing
Format: Article
Language:English
Subjects:
acne
active pharmaceutical ingredients
Anti-Inflammatory Agents
Cosmeceutical
Cosmeceuticals - chemistry
Cosmetic
cosmetics
Cosmetics - chemistry
drugs
emulsions
gels
industry
Nanocrystal
nanocrystals
Nanoparticles - chemistry
permeability
Pharmaceutical Preparations
solubility
Topical delivery
Vehicle
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Summary:The main issues with local delivery of cosmetics are their high sensitivity and limited drug loading of active pharmaceutical ingredient. Nanocrystal technology offers consumers cutting-edge and effective products and exhibits enormous development potential in the beauty business as a new delivery method to address the issue of low solubility and low permeability of sensitive chemicals. In this review, we described the processes for making NCs, along with the impacts of loading and the uses of different carriers. Among them, nanocrystalline loaded gel and emulsion are widely used and may further improve the stability of the system. Then, we introduced the beauty efficacy of drug NCs from five aspects: anti-inflammation and acne, anti-bacterial, lightening and freckle removal, anti-aging as well as UV protection. Following that, we presented the current scenario about stability and safety. Finally, the challenges and vacancy were discussed along with the potential uses of NCs in the cosmetics industry. This review serves as a resource for the advancement of nanocrystal technology in the cosmetics sector. [Display omitted] •Drug NCs with high loading capacity show great potential in cosmetology.•Challenges in the transition from studies to practice using carrier-loaded NCs.•Multiple beauty benefits and smart technology promote the upgrading of cosmetics.•Nanosized traditional Chinese medicine offers strategies for the application of NCs.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2023.113385