Prehospital Treatment of Benzodiazepine-Resistant Pediatric Status Epilepticus with Parenteral Ketamine: A Case Series

We report the initial six pediatric patients treated with ketamine for benzodiazepine-resistant status epilepticus in an urban, ground-based emergency medical services (EMS) system. Evidence for ketamine as a second-line agent for both adult and pediatric refractory seizure activity in the hospital...

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Bibliographic Details
Published in:Prehospital emergency care 2023-10, Vol.27 (7), p.1-926
Main Authors: Perlmutter, Michael, Price, Mark, Kothari, Kathryn, Rafique, Zubaid, Rogers Keene, Kelly, De La Rosa, Xavier, Weinstein, Elizabeth, Patrick, Casey
Format: Article
Language:English
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Summary:We report the initial six pediatric patients treated with ketamine for benzodiazepine-resistant status epilepticus in an urban, ground-based emergency medical services (EMS) system. Evidence for ketamine as a second-line agent for both adult and pediatric refractory seizure activity in the hospital setting has increased over the past decade. The availability of an inexpensive and familiar second-line prehospital anti-epileptic drug option is extremely desirable. We believe these initial data demonstrate promising seizure control effects without significant respiratory depression, indicating a potential role for ketamine in the EMS treatment of pediatric benzodiazepine-refractory seizures.
ISSN:1090-3127
1545-0066
DOI:10.1080/10903127.2023.2221967