Biomimetic Approach toward Kinetically Stable AIE-Gens under Physiological Conditions

Many AIE-gens suffer from excessive hydrophobicity, and their kinetic stability in aqueous condition is not warranted. Here, we introduce phosphorylcholine, a zwitterionic group ubiquitously found in biological membranes, onto the tetraphenylethene core structure to yield AIE nanoparticles stable in...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2023-06, Vol.127 (23), p.5257-5262
Main Authors: Wu, Bingze, Hu, Kan, Wang, Xiao, Zhang, Guoqing
Format: Article
Language:English
Subjects:
B: Biomaterials and Membranes
Biomimetics
Nanoparticles - chemistry
Phosphorylcholine - chemistry
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Summary:Many AIE-gens suffer from excessive hydrophobicity, and their kinetic stability in aqueous condition is not warranted. Here, we introduce phosphorylcholine, a zwitterionic group ubiquitously found in biological membranes, onto the tetraphenylethene core structure to yield AIE nanoparticles stable in both PBS buffer and cell culture. We also find that the AIE efficiency is critically reliant on the delicate balance between the hydrophilic phosphorylcholine and hydrophobic moieties.
ISSN:1520-6106
1520-5207
DOI:10.1021/acs.jpcb.3c01212