The immunomodulatory role of exosomal microRNA networks in the crosstalk between tumor-associated myeloid-derived suppressor cells and tumor cells

•MDSC-derived exosomal miRNAs and those derived from tumor cells could.•Modulate the interaction between tumor cells and MDSCs in the TME.•Tumor-associated miRNAs would affect the MDSCs immunosuppressive function.•miRNAs carried by MDSCs-Exos support the progression of MDSCs. Myeloid-derived suppres...

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Bibliographic Details
Published in:International immunopharmacology 2023-07, Vol.120, p.110267-110267, Article 110267
Main Authors: Shokati, Elham, Safari, Elahe
Format: Article
Language:English
Subjects:
Exosomes
Humans
Immunity
Immunosuppressive function
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Myeloid Cells
Myeloid-Derived Suppressor Cells
Neoplasms
Tumor Microenvironment
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Summary:•MDSC-derived exosomal miRNAs and those derived from tumor cells could.•Modulate the interaction between tumor cells and MDSCs in the TME.•Tumor-associated miRNAs would affect the MDSCs immunosuppressive function.•miRNAs carried by MDSCs-Exos support the progression of MDSCs. Myeloid-derived suppressor cells (MDSCs) are considered a heterogeneous group of immature myeloid cells engaging in aggressive tumor progression and metastasis in the tumor microenvironment (TME) of patients diagnosed with cancer, through downregulation of anti-tumor immune responses. Exosomes are small vesicles carrying specific cargos, including proteins, lipids, and MicroRNA (miRNAs). Such exosomal miRNAs delivered by MDSCs and tumor cells are short noncoding RNAs mediating some of the immunosuppressive characteristics of MDSCs in the TME. However, when it comes to cancer diseases, how these miRNAs interact with MDSCs and encourage MDSCs differentiation and function need further investigations. In this review, we discuss MDSC-derived exosomal miRNAs and those derived from tumor cells (TDE) could modulate anti-tumor immunity and regulate the interaction between tumor cells and MDSCs in the TME. Afterward, we focus on dividing miRNAs, as an important substance interacting with MDSCs and tumor cells in the TME, into those have an immunosuppressive or stimulating effect not only on MDSCs expansion, differentiation, and suppressive function but also on tumor evasion.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.110267