Comparative analysis of whole genomes and transcriptomes of Microsporum canis from invasive dermatophytosis and tinea capitis

Genomes of strains of the zoophilic dermatophyte Microsporum canis from invasive (disseminated and subcutaneous) and noninvasive (tinea capitis) infections were compared. Especially the disseminated strain showed significant syntenic rearrangements, including multiple translocations and inversions,...

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Published in:Emerging microbes & infections 2023-12, Vol.12 (1), p.2219346-2219346
Main Authors: Wang, Ruojun, Liu, Weixia, Liu, Xiao, Wan, Zhe, Sybren de Hoog, G., Li, Ruoyu, Song, Yinggai
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Biosynthesis
Comparative analysis
Dermatology
Dermatophytes
Diabetes
Fungal infections
Gene expression
Genomes
genomics
Hospitals
Humans
Microsporum - genetics
Microsporum canis
Skin
Temperature
Tinea Capitis - drug therapy
Tinea Capitis - microbiology
Transcriptome
transcriptomics
WGS
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Summary:Genomes of strains of the zoophilic dermatophyte Microsporum canis from invasive (disseminated and subcutaneous) and noninvasive (tinea capitis) infections were compared. Especially the disseminated strain showed significant syntenic rearrangements, including multiple translocations and inversions, and numerous SNPs and Indels in comparison to the noninvasive strain. In transcriptome analysis, both invasive strains were enriched for GO pathways related to components of the membrane, iron binding and heme binding, which possibly enables them to invade deeper into dermis and blood vessels. At 37 °C, invasive strains showed gene expression enriched for DNA replication, mismatch repair, N-glycan biosynthesis and ribosome biogenesis. The invasive strains were slightly less susceptible to multiple antifungal agents suggesting that acquired elevated drug resistance might be involved in the refractory disease courses. Patient with disseminated infection failed to respond to a combined antifungal treatment with itraconazole, terbinafine, fluconazole and posaconazole.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2023.2219346