Allosteric Tuning of Caspase‐7: Establishing the Nexus of Structure and Catalytic Power

Invited for the cover of this issue is the group of Michael Ashley Spies at the University of Iowa. The image depicts how mapping allosteric structure–activity relationships reveals the nexus between the active site and the remote allosteric pocket. Read the full text of the article at 10.1002/chem....

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Bibliographic Details
Published in:Chemistry : a European journal 2023-07, Vol.29 (40), p.e202301621-n/a
Main Authors: Hobbs, Kathryn F., Propp, Jonah, Vance, Nicholas R., Kalenkiewicz, Andrew, Witkin, Katie R., Spies, M. Ashley
Format: Article
Language:English
Subjects:
Allosteric properties
Caspase
Chemistry
Online Access:Get full text
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Summary:Invited for the cover of this issue is the group of Michael Ashley Spies at the University of Iowa. The image depicts how mapping allosteric structure–activity relationships reveals the nexus between the active site and the remote allosteric pocket. Read the full text of the article at 10.1002/chem.202300872. “It is the range of techniques presented here, both experimental and computational, that has enabled us to develop a mosaic understanding of the catalytic process.” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202300872).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202301621