Quantifying the hydrodynamic stress for bioprocesses

Hydrodynamic stress is an influential physical parameter for various bioprocesses, affecting the performance and viability of the living organisms. However, different approaches are in use in various computational and experimental studies to calculate this parameter (including its normal and shear s...

Full description

Saved in:
Bibliographic Details
Published in:Biotechnology progress 2023-09, Vol.39 (5), p.e3367-n/a
Main Authors: Kaya, Umut, Gopireddy, Srikanth, Urbanetz, Nora, Kreitmayer, Diana, Gutheil, Eva, Nopens, Ingmar, Verwaeren, Jan
Format: Article
Language:English
Subjects:
Bioreactors
Computational fluid dynamics
Computer applications
Fluid dynamics
Hydrodynamics
Parameters
Physical properties
Velocity distribution
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrodynamic stress is an influential physical parameter for various bioprocesses, affecting the performance and viability of the living organisms. However, different approaches are in use in various computational and experimental studies to calculate this parameter (including its normal and shear subcomponents) from velocity fields without a consensus on which one is the most representative of its effect on living cells. In this letter, we investigate these different methods with clear definitions and provide our suggested approach which relies on the principal stress values providing a maximal distinction between the shear and normal components. Furthermore, a numerical comparison is presented using the computational fluid dynamics simulation of a stirred and sparged bioreactor. It is demonstrated that for this specific bioreactor, some of these methods exhibit quite similar patterns throughout the bioreactor—therefore can be considered equivalent—whereas some of them differ significantly.
ISSN:8756-7938
1520-6033
DOI:10.1002/btpr.3367