Characterization of Treatment Response Outcomes in Chronic Pulmonary Aspergillosis: CPAnet Definitions Versus the Existing Criteria

Background The chronic pulmonary aspergillosis network (CPAnet) has recently proposed definitions for treatment outcomes in CPA. However, these definitions need to be validated. Herein, we evaluate the agreement between the existing and the CPAnet definitions for response assessment. Methods We enro...

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Published in:Mycopathologia (1975) 2023-10, Vol.188 (5), p.721-730
Main Authors: Sehgal, Inderpaul Singh, Arora, Kajal, Cornely, Oliver A., Salzer, Helmut J. F., Dhooria, Sahajal, Prasad, Kuruswamy Thurai, Garg, Mandeep, Rudramurthy, Shivaprakash M., Muthu, Valliappan, Aggarwal, Ashutosh Nath, Chakrabarti, Arunaloke, Agarwal, Ritesh
Format: Article
Language:English
Subjects:
Accountants
Aspergillosis
Biomedical and Life Sciences
Clinical outcomes
Comparative analysis
Eukaryotic Microbiology
Fungal infections
Itraconazole
Life Sciences
Medical Microbiology
Microbial Ecology
Microbiology
Original Article
Patient outcomes
Plant Sciences
Pulmonary aspergillosis
Tiotropium
Weight
Weight loss
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Summary:Background The chronic pulmonary aspergillosis network (CPAnet) has recently proposed definitions for treatment outcomes in CPA. However, these definitions need to be validated. Herein, we evaluate the agreement between the existing and the CPAnet definitions for response assessment. Methods We enrolled consecutive treatment-naïve CPA subjects (between January 2021 and June 2021) who received six months of itraconazole therapy and followed them for an additional six months after treatment discontinuation. We retrospectively applied the CPAnet criteria and compared the agreement between the existing and the CPAnet criteria for response assessment (primary objective). We also assessed if adding weight loss (> 5% from baseline) as a component improved the performance of the CPAnet criteria. Results We included 43 (mean age, 47.4 years) CPA subjects. The existing and the CPAnet criteria categorized 29 (67.4%) and 30 (69.8%) subjects as treatment success, respectively, at treatment completion. There was substantial (kappa = 0.73; p  
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-023-00751-z